Physical activity before and after cancer diagnosis and mortality risk in three large prospective cohorts.
Cancer Causes Control
; 2024 Oct 08.
Article
em En
| MEDLINE
| ID: mdl-39377971
ABSTRACT
PURPOSE:
Physical activity (PA) can improve cancer survival; however, whether the timing of PA differentially affects mortality risk is unclear. We evaluated the association between PA levels pre- and post-diagnosis and mortality risk in the Women's Health Study (WHS), Physicians' Health Study (PHS)-I, and PHS-II prospective cohorts.METHODS:
We categorized PA pre- and post-diagnosis as active (WHS ≥ 7.5 metabolic equivalent (MET)-h/week; PHS vigorous PA ≥ 2-4 times/week) or inactive. We analyzed changes in pre- and post-diagnosis PA levels as four joint categories (1) Inactive â Inactive, (2) Active â Inactive, (3) Inactive â Active, and (4) Active â Active, on mortality risk using multivariable Cox proportional hazards regression.RESULTS:
We identified 10,541 participants with incident cancer and 3,696 deaths during follow-up. Compared to maintaining inactivity in both periods, remaining active pre- and post-diagnosis observed lower all-cause (Hazard Ratio [95% confidence interval] WHS 0.55 [0.47-0.64]; PHS-I 0.77 [0.67-0.88]), cancer (WHS 0.55 [0.45-0.67]; PHS-I 0.75; [0.61-0.92]) and non-cancer/cardiovascular disease (CVD) mortality risks (WHS 0.49 [0.38-0.65]). Similarly, becoming active post-diagnosis was associated with lower all-cause (WHS 0.60 (0.48-0.75]; PHS-I 0.72 [0.61-0.88]), cancer (WHS 0.65 [0.49-0.86]; PHS-I 0.64 [0.49-0.84]), and non-cancer/CVD mortality risk (WHS 0.49 [0.33-0.75]). Being active pre- and post-diagnosis was associated with lower mortality risks in separate analyses, although significance differed by cohort and outcome.CONCLUSIONS:
Remaining active pre- and post-diagnosis and becoming active post-diagnosis may be associated with improvements in cancer survival, however, research is needed across diverse cancer populations.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Cancer Causes Control
/
Cancer causes and control
/
Cancer causes control
Assunto da revista:
EPIDEMIOLOGIA
/
NEOPLASIAS
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos
País de publicação:
Holanda