Biological activity of Sch 14342, an aminoglycoside antibiotic coproduced in the gentamicin fermentation.
Antimicrob Agents Chemother
; 2(6): 464-9, 1972 Dec.
Article
em En
| MEDLINE
| ID: mdl-4670439
Sch 14342 is an aminoglycoside antibiotic coproduced as a minor component in the gentamicin fermentation. Sch 14342 was found to have the same antibacterial spectrum as gentamicin in vitro and in vivo, and was approximately one-third as active in mouse protection tests. Sch 14342 relative to gentamicin was one-third as toxic in acute tests in mice, one-eighth as toxic in renal toxicity tests in dogs, and an estimated one-tenth as toxic in cat ataxia tests. Sch 14342 possesses a significantly improved therapeutic index relative to gentamicin with reference to ataxia potential and renal toxicity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aminoglicosídeos
/
Antibacterianos
Limite:
Animals
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
1972
Tipo de documento:
Article
País de publicação:
Estados Unidos