Regulation of B cell growth and differentiation via CD21 and CD40.
Eur J Immunol
; 26(9): 2203-7, 1996 Sep.
Article
em En
| MEDLINE
| ID: mdl-8814268
Stimulation in vitro of murine splenic B cells by lipopolysaccharide, anti-kappa Sepharose, anti-CD40 or allo-reactive T helper cells all up-regulated CD21 and CD23 surface expression. Neither anti-CD21 nor anti-CD23 antibodies induced B cell growth or differentiation when added in soluble form or coupled to Sepharose. However, anti-CD40-stimulated B cells showed increased proliferation in the presence of anti-CD21 antibodies coupled to Sepharose; co-stimulation via CD21 also induced differentiation to immunoglobulin secretion in a fraction of anti-CD40-stimulated B cells. Furthermore, anti-CD40 antibodies inhibited differentiation to immunoglobulin secretion induced by lipopolysaccharide and, hence, appears to be a dominant negative signal for B cell differentiation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Receptores de Complemento 3d
/
Antígenos CD40
Limite:
Animals
Idioma:
En
Revista:
Eur J Immunol
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Suécia
País de publicação:
Alemanha