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Regulation of B cell growth and differentiation via CD21 and CD40.
Axcrona, K; Gray, D; Leanderson, T.
Afiliação
  • Axcrona K; Department of Cell and Molecular Biology, Lund University, Sweden. Karol.Axcrona@immuno.lu.se
Eur J Immunol ; 26(9): 2203-7, 1996 Sep.
Article em En | MEDLINE | ID: mdl-8814268
Stimulation in vitro of murine splenic B cells by lipopolysaccharide, anti-kappa Sepharose, anti-CD40 or allo-reactive T helper cells all up-regulated CD21 and CD23 surface expression. Neither anti-CD21 nor anti-CD23 antibodies induced B cell growth or differentiation when added in soluble form or coupled to Sepharose. However, anti-CD40-stimulated B cells showed increased proliferation in the presence of anti-CD21 antibodies coupled to Sepharose; co-stimulation via CD21 also induced differentiation to immunoglobulin secretion in a fraction of anti-CD40-stimulated B cells. Furthermore, anti-CD40 antibodies inhibited differentiation to immunoglobulin secretion induced by lipopolysaccharide and, hence, appears to be a dominant negative signal for B cell differentiation.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos B / Receptores de Complemento 3d / Antígenos CD40 Limite: Animals Idioma: En Revista: Eur J Immunol Ano de publicação: 1996 Tipo de documento: Article País de afiliação: Suécia País de publicação: Alemanha
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos B / Receptores de Complemento 3d / Antígenos CD40 Limite: Animals Idioma: En Revista: Eur J Immunol Ano de publicação: 1996 Tipo de documento: Article País de afiliação: Suécia País de publicação: Alemanha