[Current concepts on cartilage collagens and their association with disease]. / Conceptos actuales sobre colágenas de cartílago y su asociación con enfermedades.
Rev Invest Clin
; 48(4): 311-9, 1996.
Article
em Es
| MEDLINE
| ID: mdl-8966395
The main functional role of the collagenous cartilage fibers is to form a stable network to counteract the hydrodynamic pressure generated by the highly hydrodynamic proteoglycan aggregates. The main collagen present in human cartilage is type II, but other proteins such as type IV, VI, IX, X, XI and XIV are also found albeit in small quantities. Several transgenic mice have been developed to study the structural abnormalities as they relate to human disease. Similarly, the study of these structural abnormalities has renewed the interest regarding their pathogenetic role in some hereditary and acquired diseases of cartilage in humans. It is hoped that gene therapy will help correct these abnormalities. We review here these topics.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cartilagem Articular
/
Colágeno
/
Doenças do Colágeno
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
Es
Revista:
Rev Invest Clin
Assunto da revista:
MEDICINA
Ano de publicação:
1996
Tipo de documento:
Article
País de publicação:
México