Products from mast cells influence T lymphocyte proliferation and cytokine production--relevant to allergic asthma?
Immunol Lett
; 57(1-3): 47-51, 1997 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-9232424
In IgE allergic diseases both mast cells and T lymphocytes play an important role. Whereas mast cels have been implicated in immediate allergic responses, T lymphocytes mediate subsequent late phase responses and chronic inflammation. Here we review possible links between the early mast cell activation and the later T lymphocyte stimulation. Products from mast cells were found to exert effects on T lymphocytes. Human Mast Cell line-1 (HMC-1) mast cells modulated proliferation and cytokine production of a human CD8+ T-cell clone in vitro. Activated mast cells seemed to drive this CD8+ T-cell clone towards a more pronounced T (helper) 1 type of response, simultaneously decreasing T-cell numbers. It is hypothesized that this might be a negative feed back mechanism operating in allergic subjects, by which the Th2-driven IgE production and eosinophilia are counteracted.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Citocinas
/
Linfócitos T CD8-Positivos
/
Mastócitos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Immunol Lett
Ano de publicação:
1997
Tipo de documento:
Article
País de publicação:
Holanda