Genotoxicity of an extract of Calendula officinalis L.
J Ethnopharmacol
; 61(1): 49-55, 1998 May.
Article
em En
| MEDLINE
| ID: mdl-9687081
A fluid extract of Calendula officinalis L. displayed genotoxic properties when assayed for mitotic segregation in the heterozygous diploid D-30 of Aspergillus nidulans. The extract of Calendula exhibited dose-dependent toxicity and genotoxicity (both mitotic crossing-over and chromosome malsegregation being observed) to Aspergillus in the range of five plate concentrations from 0.1 to 1.0 mg of solids/ml assayed. Mutagenicity testing with the Salmonella/microsome assay in strains TA 1535, TA 1537, TA 98 and TA 100 was negative in a plate incorporation protocol, with concentrations ranging from 50 to 5000 microg/plate (+/- S9). The mouse bone marrow micronucleus test, where the extract was dosed orally up to 1 g/kg for 2 days, was also negative.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
Limite:
Animals
País/Região como assunto:
Caribe
/
Cuba
Idioma:
En
Revista:
J Ethnopharmacol
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Cuba
País de publicação:
Irlanda