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Clinical features of food protein-induced enterocolitis syndrome.
Sicherer, S H; Eigenmann, P A; Sampson, H A.
Afiliação
  • Sicherer SH; Division of Pediatric Allergy and Immunology, Jaffe Food Allergy Institute, Mount Sinai Medical Center, New York, New York, USA.
J Pediatr ; 133(2): 214-9, 1998 Aug.
Article em En | MEDLINE | ID: mdl-9709708
OBJECTIVE: To describe the clinical characteristics of food protein-induced enterocolitis syndrome (FPIES), a symptom complex of severe vomiting and diarrhea occurring several hours after the ingestion of particular food proteins in infants. STUDY DESIGN: Retrospective review of a referral population. RESULTS: Sixteen patients had typical FPIES; 11 reacted to milk, 11 to soy, and 7 to both. Mean age at diagnosis was 7 weeks for milk reactivity and 8 weeks for soy reactivity. Two patients also had rice- and pea-induced FPIES. Among 14 patients who were followed up for a median period of 25 months, loss of sensitivity to milk occurred in 6 of 10 patients and loss of sensitivity to soy occurred in 2 of 8. Six additional cases of FPIES were considered atypical: 1 patient had late-onset disease caused by poultry, and in 5 patients IgE antibody to milk or soy developed. During supervised food challenges with milk and soy, the peripheral blood neutrophil count rose over 3500 cells/mm3 in 9 of 10 positive challenges and did not rise above this value in the 7 negative challenges. Emergency treatment was required in 62% of challenges. CONCLUSIONS: Although most patients with FPIES are infants reactive to milk and/or soy, this diagnosis should be considered in older children and for other foods. Food-specific IgE sensitivity may develop in some patients. Standardized food challenges are helpful for diagnosis and follow-up.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Alimentares / Enterocolite / Hipersensibilidade Alimentar Tipo de estudo: Diagnostic_studies / Observational_studies Limite: Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: J Pediatr Ano de publicação: 1998 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Alimentares / Enterocolite / Hipersensibilidade Alimentar Tipo de estudo: Diagnostic_studies / Observational_studies Limite: Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Revista: J Pediatr Ano de publicação: 1998 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos