Impact of Haemophilus influenzae type b conjugate vaccine on bacterial meningitis in the Dominican Republic
Rev. panam. salud pública
; 24(3): 161-168, Sept. 2008. tab, graf
Artigo
em Inglês
| MedCarib
| ID: med-17462
Biblioteca responsável:
TT5
Localização: TT5; W1, RE712AW
ABSTRACT
OBJECTIVES:
Widespread use of Haemophilus influenzae type b (Hib) vaccines has dramatically reduced the burden of Hib disease throughout the Americas. Few studies have evaluated the impact of Hib vaccination on non-culture-confirmed disease. This study analyzed trends in probable bacterial meningitis before and after the introduction of Hib vaccine in the Dominican Republic and estimated vaccine effectiveness against Hib meningitis.METHODS:
Meningitis cases among children < 5 years of age were identified from admission records of the main pediatric hospital in Santo Domingo during 1998 - 2004. Laboratory criteria were used to classify meningitis cases with probable bacterial etiology; confirmed cases had positive bacterial culture or antigen detection in cerebrospinal fluid. Cumulative incidence rates of confirmed and probable bacterial meningitis were calculated for children living in the National District. Confirmed cases of Hib meningitis were enrolled in a case control study with age- and neighborhood-matched control children to calculate vaccine effectiveness.RESULTS:
Before vaccine introduction, annual rates of meningitis with probable bacterial etiology were 49 cases per 100000 children < 5 years old; Hib accounted for 60 percent of confirmed bacterial cases. During 2002 - 2004, after vaccine introduction, annual rates of probable bacterial meningitis were 65 percent lower at 16 cases per 100000, and Hib accounted for 26 percent of confirmed cases. Rates of Hib meningitis and probable bacterial meningitis with no determined etiology declined by 13 and 17 cases per 100000, respectively.CONCLUSIONS:
Introduction of Hib vaccine substantially reduced the incidence of confirmed and probable bacterial meningitis in the Dominican Republic. The estimated impact of Hib vaccination was twice as great when non-culture-confirmed disease was included
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
Doenças Negligenciadas
/
ODS3 - Meta 3.3 Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
/
Doenças Negligenciadas
/
Zoonoses
/
Meningite
Base de dados:
MedCarib
Assunto principal:
Imunização
/
Meningites Bacterianas
/
Haemophilus influenzae tipo b
/
República Dominicana
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
/
Lactente
País/Região como assunto:
Caribe Inglês
/
Dominica
/
República Dominicana
Idioma:
Inglês
Revista:
Rev. panam. salud pública
Ano de publicação:
2008
Tipo de documento:
Artigo
Instituição/País de afiliação:
Departamento de Enfermedades Infecciosas/Dominican Republic
/
Division of Bacterial Diseases/United States of America
/
Programa Ampliado de Inmunización/Dominican Republic