The fragility of normal and abnormal erythrocytes in a controlled hydrodynamic shear field
Br J Haematol
; 37(3): 379-89, Nov. 1977.
Artigo
em Inglês
| MedCarib
| ID: med-1758
Biblioteca responsável:
JM3.1
Localização: JM3.1; RB145.A1B7
ABSTRACT
Fresh human erythrocytes (suspended in a compatible isotonic viscous saline medium containing plasma) were disrupted by the uniform shear stresses generated in the laminar flow field of a conventional cone and plate viscometer. A range of normal fragilities were established and blood samples from patients having certain well-defined haematological abnormalities were found to be partially or completely outside these limits. The present technique is sensitive enough to distinguish between young and old cell fraction isolated from the same original population and also appears to be able to resolve discrete sub-populations having different mechanical fragilities within unfractionated samples from certain patients (e.g macrocytosis). This technique provide additional information which could aid or facilitate diagnosis and might eventually form the basis of a routine screening test in clinical haematology.(AU)
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Base de dados:
MedCarib
Assunto principal:
Fragilidade Osmótica
/
Eritrócitos
/
Eritrócitos Anormais
Idioma:
Inglês
Revista:
Br J Haematol
Ano de publicação:
1977
Tipo de documento:
Artigo