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Urinary 5-L-oxoproline (pyroglutamic acid) excretion is greater in infants in Jamaican than in infants in England
Persaud, Chandarika; Forrester, Terrence E; Jackson, Alan A.
Afiliação
  • Persaud, Chandarika; University of Southampton, Southampton, UK. Institute of Human Nutrition
  • Forrester, Terrence E; University of the West Indies, Mona, Jamaica. Tropical Metabolism Research Institute
  • Jackson, Alan A; University of Southampton, Southampton, UK. Institute of Human Nutrition
Eur J clin Nutr ; 51(8): 510-3, Aug. 1997.
Article em En | MedCarib | ID: med-1769
Biblioteca responsável: JM3.1
Localização: JM3.1; Reprint Collection
ABSTRACT

OBJECTIVE:

To determine the pattern of excretion in urine of 5-L-oxoproline, as a measure of glycine status, during the first six weeks of life in Jamaican infants.

DESIGN:

Spot samples of urine were collected from term and preterm infants at birth and longitudinally to four weeks of age, or at six weeks of age. 5-L-oxoproline was isolated by column chromatography and hydrolysed to L-glutamic acid, which was measured enzymatically and results expressed relative to creatinine excretion.

SETTING:

Maternity wards and postnatal clinic of the University Hospital of the West Indies.

SUBJECTS:

African-Caribbean infants, 19 term and 21 preterm, from birth to four weeks of age, and 79 term infants at six weeks of age.

RESULTS:

There was no difference between term and preterm infants. Excretion of 5-L-oxoproline increased progressively from birth, 141 æmol/mmol creatinine at four weeks of age. At six weeks of age, excretion was significantly greater than at birth or four weeks of age, 525 æmol/mmol creatinine. Compared with infant born in England, the excretion of 5-L-oxoproline was not different at birth, but was significantly greater in Jamaican infant at six weeks of age.

CONCLUSIONS:

Glycine status, indicated by increased excretion of 5-L-oxoproline, is marginal in Jamaican infants at six weeks of age, and this is possibly reflects a limitation in the endogenous biosynthesis of glycine due to a dietary limitation of folate or vitamin B-12. (AU)
Assuntos
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Coleções: 01-internacional Base de dados: MedCarib Assunto principal: Ácido Pirrolidonocarboxílico / Recém-Nascido / Recém-Nascido Prematuro / Creatinina Limite: Female / Humans / Infant / Male País/Região como assunto: Caribe ingles / Europa / Jamaica Idioma: En Revista: Eur J clin Nutr Ano de publicação: 1997 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MedCarib Assunto principal: Ácido Pirrolidonocarboxílico / Recém-Nascido / Recém-Nascido Prematuro / Creatinina Limite: Female / Humans / Infant / Male País/Região como assunto: Caribe ingles / Europa / Jamaica Idioma: En Revista: Eur J clin Nutr Ano de publicação: 1997 Tipo de documento: Article