Interaction of HIV RNA with peptides detected by acoustic shear wave sensor operated in an on-line format.
Methods in molecular biology
; 385: 205-214, 2007. ilusgraf
Artigo
em Inglês
| MedCarib
| ID: med-17739
Biblioteca responsável:
TT5
ABSTRACT
Acoustic wave sensors are now widely used in various clinical applications because they allow real-time data to be rapidly obtained. In this chapter we describe the use of the thickness shear mode (TSM) acoustic wave sensor to study the interaction between the transactivation responsive region (TAR) of the HIV-1 mRNA and short peptides derived from the regulatory Tat protein as well as with two inhibitor molecules, namely neomycin and streptomycin. The interaction between the TAR-Tat system is a target for the development of antiviral drugs.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Trinidad e Tobago
/
Produtos do Gene tat
/
HIV-1
Limite:
Humanos
País/Região como assunto:
Caribe Inglês
/
Trinidad e Tobago
Idioma:
Inglês
Revista:
Methods in molecular biology
Ano de publicação:
2007
Tipo de documento:
Artigo
Instituição/País de afiliação:
The Scripps Research Institute/United States of America
/
The University of the West Indies/Trinidad and Tobago
/
University of Toronto/Canada