Failure of combined choroquine and high-dose primaquine therapy for Plasmodium vivax malaria acquired in Guyana, South America
Clin Infect Dis
; 23(5): 1171-3, Nov. 1996.
Artigo
em Inglês
| MedCarib
| ID: med-2083
Biblioteca responsável:
JM3.1
Localização: JM3.1
ABSTRACT
The presence of chloroquine-resistant Plasmodium vivax malaria in the New World has been suspected but not confirmed. We report the cases of three patients who acquired vivax malaria in Guyana, South America, and for whom standard chloroquine therapy (25mg/kg) failed despite therapeutic blood levels. The optimal treatment of Chloroquine-resistant P. vivax malaria is unknown, but recent studies suggest that a combination of chloroquine (25 mg/kg) and high-dose primaquine (2.5 mg/kg over 48 hours) is effective therapy. Two of our patients had recurrences of P. vivax malaria 6-8 weeks after receiving directly observed therapy with this combination. These cases confirm the presence of chloroquine-resistant P. vivax in Guyana and emphasize the need for better treatment regimens for chloroquine-resistant and primaquine-resistant P. vivax malaria.(AU)
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Coleções:
Bases de dados internacionais
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Malária
/
Doenças Negligenciadas
Base de dados:
MedCarib
Assunto principal:
Plasmodium vivax
/
Primaquina
/
Cloroquina
/
Malária Vivax
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Humanos
/
Masculino
País/Região como assunto:
América do Sul
/
Caribe Inglês
/
Guiana
Idioma:
Inglês
Revista:
Clin Infect Dis
Ano de publicação:
1996
Tipo de documento:
Artigo