Comparison of methods of assessing vitamin A status in children
J Am Coll Nutr
; 15(5): 439-49, Oct. 1996.
Artigo
em Inglês
| MedCarib
| ID: med-2095
Biblioteca responsável:
JM3.1
Localização: JM3.1
ABSTRACT
A study of children (2 - 8 years; n = 613) in Belize, Central America, was conducted to determine what proportion of the children might be at risk of vitamin A (vit A) deficiency. The data provide an opportunity to compare results of three methods of assessing vit A status in a population which was not severely malnourished. Serum retinyl ester concentrations were also determined; their relevance to one of the tests, the relative dose response (RDR) test, is discussed. METHODS:
The three methods of assessing vit A status were RDR test, fasting serum rintol concentration, and conjunctival impression cytology (CIC). Retinol-binding protein (RBP), serum retinyl esters and serum zinc concentrations were also determined.RESULTS:
Inadequate vit A status was indicated for 17 percent of subjects by the RDR test (14 percent cutoff), for 24 percent by fasting serum retinol concentration (< 0.87 mumol/L), and for 49 prcent by abnormal. CIC score. Retinyl esters constituted 24 percent of serum retinoids at the time (5 hours after a retinyl palmitate dose) at which the second blood sample is taken for the RDR test. Regresssion trees analyses (CART) indicated ethnicity was a predictor of RDR score; ethnicity, stunting and age were predictors of fasting serum retinol concentration; ethnicity and stunting were predictors of O-hour retinyl ester concentration.CONCLUSION:
The three indices of vit A status did not identify the same individuals nor indicate the same percentage of the population to be at risk for hours compared to those at O hours suggest that insufficient retinol may have been taken up by the liver at 5 hours to release all accumulated retinol-binding protein (RBP) in deficient individuals; prevalence of vit A deficiency might therefore be underestimated by the RDR test. The selection of ethnicity as a predictor of RDR score and of O-hour retinol and retinyl ester concentrations suggests that factors other than vit A status affect vit A metabolism and may affect the RDR test.(AU)
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Coleções:
Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Vitamina A
/
Estado Nutricional
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
/
Fatores de risco
Limite:
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
América Central
/
Belize
/
Caribe Inglês
Idioma:
Inglês
Revista:
J Am Coll Nutr
Ano de publicação:
1996
Tipo de documento:
Artigo