Lipids, apolipoprotein-E genotypes and other risk factors of patients with coronary artery disease in Curacao, the Netherlands Antilles - abstract
West Indian med. j
; 44(Suppl 2.): 16, April, 1995.
Artigo
em Inglês
| MedCarib
| ID: med-5803
Biblioteca responsável:
JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
We studied lipids, apolipoprotein-E genotypes (apoe) and other coronary artery disease (CAD) risk factors of 67 CAD patients (male/female ratio 6) in Curacao. Compared with 57 controls, male CAD patients had higher cholesterol, triglycerides, LDL-cholesterol, apo-apo-B, apo-B/apo-Al, and decreased HDL-cholesterol and HDL-cholesterol/cholesterol. Other CAD risk factors were increased fasting glucose, HbA1c and prevalences of renal disease, diabetes mellitus type II (DM-II), positive CAD family history and cigarette smoking. Male CAD patients had higher plasma O-tocopherol eq but normal plasma O-tocopherol eq/ total lipid and á-carotene/total lipid; 38.5 percent of male CAD patients and 37.8 percent of male controls had Lp(a) above 300 mg/l. Compared with 29 female controls, female CAD patients had higher fasting plasma glucose, HbA 1c and prevalences of renal disease and DM-II. Predicting factors for CAD development in the whole CAD group were DM-II, cigarette smoking, apo-i3/i4 and apoi4. Apo-i was associated with lower DLH-and higher LDL-cholesterol. We conclude that classical atherogenic lipid profiles are associated with CAD in Curacao. It is questionable whether Lp(a) contributes to CAD in a predominantly negroid population. DM-II may considerably contribute to CAD development, notably in women. Apoi4, possibly because of induction of atherogenic lipid profile, is likely to be a risk factor (AU)
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Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Apolipoproteínas E
/
Doença das Coronárias
/
Lipídeos
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Antilhas Neerlandesas
/
Caribe
/
Caribe Inglês
Idioma:
Inglês
Revista:
West Indian med. j
Ano de publicação:
1995
Tipo de documento:
Artigo
/
Congresso e conferência