Systemic lupus erythematosus, rheumatoid arthritis and HLA phenotypes in Jamaicans
West Indian med. j
; 44(1): 10-13, Mar. 1995.
Artigo
em Inglês
| MedCarib
| ID: med-7235
Biblioteca responsável:
JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
The HLA phenotypes were investigated in 30 Jamaican patients with systemic lupus erythematosus (SLE), 30 with rheumatoid arthritis (RA) an d forty healthy controls. HLA phenotypes were determined by the microcytotoxicity technique, using commercially prepared typing trays. In this study, the HLA phenotypic associations with SLE (HLA-B14, RR 4.3 HLA-A28, RR 4.3) were not statiscally significant. However, a statistically significant lack of HLA-A9 (p<0.01;CP<0.1) was observed in SLE patients compared to healthy controls. In RA patients, a statistically significant associations was noted with HLA-A2 (RR5.1; CP<0.01). No HLA class 11 associations were noted with SLE. Class 11 associations with RA did not achieve statistical significance but included those previously established in other populations. The preliminary data obtained from this study indicate differences in the patterns of HLA phenotypes in Jamaican patients with SLE and RA compared to those observed in such patients elsewhere. Further studies involving larger groups of patients and typing at the serological, cellular and molecular levels are clearly warranted (AU)
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Coleções:
Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Artrite Reumatoide
/
Antígenos HLA
/
Lúpus Eritematoso Sistêmico
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Limite:
Humanos
País/Região como assunto:
Caribe Inglês
/
Jamaica
Idioma:
Inglês
Revista:
West Indian med. j
Ano de publicação:
1995
Tipo de documento:
Artigo