Comparative effectiveness of co-trimoxazole and tetracycline in the treatment of cholera
Bulletin of the Pan American Health Organization (PAHO)
; 30(1): 36-42, Mar. 1996.
Artigo
em Inglês
| PAHO
| ID: pah-22288
Biblioteca responsável:
US1.1
Localização: US1.1, PAHO COLL
ABSTRACT
The purpose of the study reported here was to compare the bactericidal effectiveness of tetracycline and co-trimoxazole (a combination of sulfamethoxazole and trimethoprim) in treating cholera. The study, an open-ended random trial using adult patients with cholera cases confirmed by stool culture, was carried out in March 1993 at the Cholera Treatment Unit (CTU) of the Hospital de Apoyo Departamental María Auxiliadora in Lima, Peru. A total of 107 subjects were divided into two groups (A and B). The 50 in Group A received 500 mg of tetracycline orally every 6 hours for 3 days; the 57 in Group B received co-trimoxazole (160 mg of trimethoprim and 800 mg of sulfamethoxazole) orally every 12 hours for 3 days. The two groups were comparable in terms of age, sex, duration of symptoms prior to hospital admission, time at which antibiotic treatment was initiated, and clinical evolution. Control stool cultures of specimens obtained after treatment showed Vibrio cholerae 0-1 present in 2 percent of the Group A and 12.3 percent of the Group B patients, and also showed V. cholerae non-0-1 present in 2 percent of the group A patients and 3.5 percent of the Group B patients. Overall, it was concluded that both therapeutic treatment regimens were effective and that the strains of V. cholerae observed in the southern sector of the city of Lima were still susceptible to both antibiotics (AU)
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Texto completo:
Disponível
Coleções:
Bases de dados de organismos internacionais
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
Doenças Negligenciadas
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
/
Cólera
/
Doenças Negligenciadas
Base de dados:
PAHO
Assunto principal:
Tetraciclina
/
Vibrio cholerae
/
Resistência Microbiana a Medicamentos
/
Cólera
Tipo de estudo:
Ensaio clínico controlado
País/Região como assunto:
América do Sul
/
Peru
Idioma:
Inglês
Revista:
Bulletin of the Pan American Health Organization (PAHO)
Ano de publicação:
1996
Tipo de documento:
Artigo