Field application of a colorimetric method of assaying chloroquine and desethylchloroquine in urine
Bulletin of the World Health Organization (WHO)
; 66(4): 485-90, 1988. Tab
Artigo
em Inglês
| PAHO
| ID: pah-2234
Biblioteca responsável:
US1.1
Localização: US1.1, WHO COLL
ABSTRACT
In a study in western Kenya of malaria-infected adult women who had been treated with chloroquine, we compared the level of chloroquine and its principal metabolite, desethylchloroquine, in urine, measured using a newly developed modified Haskins test, with the level of chloroquine in whole blood, determined by high-performance liquid chromatography. Over a 28-day follow-up period, 277 matched urine and blood samples from 81 women were evaluated. A high correlation was observed between the level of chloroquine in whole blood (in ug/l) and that of chloroquine+desethylchloroquine in urine (in ug/l). The test was easily performed and may be useful for monitoring use of chloroquine in a community and determining a pre-study or post-treatment ingestion or absorption of the drug in in vivo studies of parasite sensitivity
Buscar no Google
Coleções:
Bases de dados de organismos internacionais
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Malária
Base de dados:
PAHO
Assunto principal:
Cloroquina
/
Cromatografia Líquida de Alta Pressão
/
Colorimetria
Idioma:
Inglês
Revista:
Bulletin of the World Health Organization (WHO)
Ano de publicação:
1988
Tipo de documento:
Artigo