Influence of the degree of dispersion in the aqueous phase on the immunogenicity of oil-adjuvanted foot-and-mouth disease vaccine

ABSTRACT

Both primary emulsion (water-in-oil) and double emulsion (water-in-oil-water) foot-and-mouth disease vaccines with different viscosities produced exellent persistent levels of neutralizing antibodies. The degree of dispersion of the aqueous antgenic phase in the oily phase, which determined the viscosity of the vaccine, did not have a demonstrable effect on the long-term immunogenicity of the vaccines.