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Mutational dynamics and transmission properties of SARS-CoV-2 superspreading events in Austria
Alexandra Popa; Jakob-Wendelin Genger; Michael Nicholson; Thomas Penz; Daniela Schmid; Stephan W Aberle; Benedikt Agerer; Alexander Lercher; Lukas Endler; Henrique Colaco; Mark Smyth; Michael Schuster; Miguel Grau; Francisco Martinez Jimenez; Oriol Pich; Wegene Tamire Borena; Erich Pawelka; Zsofia Keszei; Martin Senekowitsch; Jan Laine; Judith Aberle; Monika Redlberger-Fritz; Mario Karolyi; Alexander Zoufaly; Sabine Maritschnik; Martin Borkovec; Peter Hufnagl; Manfred Nairz; Guenter Weiss; Michael T. Wolfinger; Dorothee von Laer; Giulio Superti-Furga; Nuria Lopez-Bigas; Elisabeth Puchhammer-Stoeckl; Franz Allerberger; Franziska Michor; Christoph Bock; Andreas Bergthaler.
Afiliação
  • Alexandra Popa; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
  • Jakob-Wendelin Genger; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
  • Michael Nicholson; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health
  • Thomas Penz; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
  • Daniela Schmid; Austrian Agency for Health and Food Safety
  • Stephan W Aberle; Center for Virology, Medical University of Vienna
  • Benedikt Agerer; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
  • Alexander Lercher; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
  • Lukas Endler; Department of Biomedical Sciences, University of Veterinary Medicine
  • Henrique Colaco; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
  • Mark Smyth; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
  • Michael Schuster; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
  • Miguel Grau; Institute for Research in Biomedicine
  • Francisco Martinez Jimenez; IRB
  • Oriol Pich; Institute for Research in Biomedicine
  • Wegene Tamire Borena; Institute of Virology, Medical University Innsbruck
  • Erich Pawelka; Department of Medicine IV, Kaiser Franz Josef Hospital
  • Zsofia Keszei; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
  • Martin Senekowitsch; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
  • Jan Laine; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
  • Judith Aberle; Center for Virology, Medical University of Vienna
  • Monika Redlberger-Fritz; Center for Virology, Medical University of Vienna
  • Mario Karolyi; Department of Medicine IV, Kaiser Franz Josef Hospital
  • Alexander Zoufaly; Department of Medicine IV, Kaiser Franz Josef Hospital
  • Sabine Maritschnik; Austrian Agency for Health and Food Safety
  • Martin Borkovec; Austrian Agency for Health and Food Safety
  • Peter Hufnagl; Austrian Agency for Health and Food Safety
  • Manfred Nairz; Department of Internal Medicine II, Medical University of Innsbruck
  • Guenter Weiss; Department of Internal Medicine II, Medical University of Innsbruck
  • Michael T. Wolfinger; University of Vienna, Austria
  • Dorothee von Laer; Institute of Virology, Medical University Innsbruck
  • Giulio Superti-Furga; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
  • Nuria Lopez-Bigas; Barcelona Institute for Research in Biomedicine
  • Elisabeth Puchhammer-Stoeckl; Medical University of Vienna
  • Franz Allerberger; Austrian Agency for Health and Food Safety
  • Franziska Michor; Dana-Farber Cancer Institute
  • Christoph Bock; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
  • Andreas Bergthaler; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Preprint em Inglês | bioRxiv | ID: ppbiorxiv-204339
ABSTRACT
Superspreading events shape the COVID-19 pandemic. Here we provide a national-scale analysis of SARS-CoV-2 outbreaks in Austria, a country that played a major role for virus transmission across Europe and beyond. Capitalizing on a national epidemiological surveillance system, we performed deep whole-genome sequencing of virus isolates from 576 samples to cover major Austrian SARS-CoV-2 clusters. Our data chart a map of early viral spreading in Europe, including the path from low-frequency mutations to fixation. Detailed epidemiological surveys enabled us to calculate the effective SARS-CoV-2 population bottlenecks during transmission and unveil time-resolved intra-patient viral quasispecies dynamics. This study demonstrates the power of integrating deep viral genome sequencing and epidemiological data to better understand how SARS-CoV-2 spreads through populations. Graphical Abstract O_FIG_DISPLAY_L [Figure 1] M_FIG_DISPLAY C_FIG_DISPLAY
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Texto completo: Disponível Coleções: Preprints Base de dados: bioRxiv Tipo de estudo: Estudo observacional Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Preprint
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: Disponível Coleções: Preprints Base de dados: bioRxiv Tipo de estudo: Estudo observacional Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Preprint