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From people to Panthera: Natural SARS-CoV-2 infection in tigers and lions at the Bronx Zoo
Denise McAloose; Melissa Laverack; Leyi Wang; Mary Lea Killian; Leonardo C Caserta; Fangfeng Yuan; Patrick K Mitchell; Krista Queen; Matthew R Mauldin; Brittany D Cronk; Susan L Bartlett; John M Sykes; Stephanie Zec; Tracy Stokol; Karen Ingerman; Martha A Delaney; Richard Fredrickson; Marina Ivancic; Melinda Jenkins-Moore; Katie Mozingo; Kerrie Franzen; Nichole Hines Bergeson; Laura Goodman; Haibin Wang; Ying Fang; Colleen Olmstead; Colleen McCann; Patrick Thomas; Erin Goodrich; Francois Elvinger; David C Smith; Suxiang Wang; Sally Slavinski; Paul P Calle; Karen Terio; Mia Kim Torchetti; Diego G Diel.
Afiliação
  • Denise McAloose; Wildlife Conservation Society
  • Melissa Laverack; Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, New York
  • Leyi Wang; Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Illinois, Urbana, Illinois, USA
  • Mary Lea Killian; National Veterinary Services Laboratories, Veterinary Services, United States Department of Agriculture, Ames, Iowa, USA
  • Leonardo C Caserta; Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, New York
  • Fangfeng Yuan; Department of Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, Illinois, USA
  • Patrick K Mitchell; Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, New York
  • Krista Queen; Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Matthew R Mauldin; Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Brittany D Cronk; Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, New York
  • Susan L Bartlett; Wildlife Conservation Society, Bronx Zoo, Bronx, New York, USA
  • John M Sykes; Wildlife Conservation Society, Bronx Zoo, Bronx, New York, USA
  • Stephanie Zec; Wildlife Conservation Society, Bronx Zoo, Bronx, New York, USA
  • Tracy Stokol; Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, New York
  • Karen Ingerman; Wildlife Conservation Society, Bronx Zoo, Bronx, New York, USA
  • Martha A Delaney; Zoological Pathology Program, College of Veterinary Medicine, University of Illinois, Illinois, USA
  • Richard Fredrickson; College of Veterinary Medicine, University of Illinois, USA
  • Marina Ivancic; Chicago Zoological Society, Chicago, Illinois, USA
  • Melinda Jenkins-Moore; National Veterinary Services Laboratories, Veterinary Services, United States Department of Agriculture, Ames, Iowa, USA
  • Katie Mozingo; National Veterinary Services Laboratories, Veterinary Services, United States Department of Agriculture, Ames, Iowa, USA
  • Kerrie Franzen; National Veterinary Services Laboratories, Veterinary Services, United States Department of Agriculture, Ames, Iowa, USA
  • Nichole Hines Bergeson; National Veterinary Services Laboratories, Veterinary Services, United States Department of Agriculture, Ames, Iowa, USA
  • Laura Goodman; Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, New York
  • Haibin Wang; Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Ying Fang; Department of Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, Illinois, USA
  • Colleen Olmstead; Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Illinois, Urbana, Illinois, USA
  • Colleen McCann; Wildlife Conservation Society, Bronx Zoo, Bronx, New York, USA
  • Patrick Thomas; Wildlife Conservation Society, Bronx Zoo, Bronx, New York, USA
  • Erin Goodrich; Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, New York
  • Francois Elvinger; Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, New York
  • David C Smith; New York State Department of Agriculture and Markets, Albany, New York, USA.
  • Suxiang Wang; Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Sally Slavinski; New York City Department of Health and Mental Hygiene, Queens, NY, USA.
  • Paul P Calle; Wildlife Conservation Society, Bronx Zoo, Bronx, New York, USA
  • Karen Terio; Zoological Pathology Program, College of Veterinary Medicine, University of Illinois, Illinois, USA
  • Mia Kim Torchetti; National Veterinary Services Laboratories, Veterinary Services, United States Department of Agriculture, Ames, Iowa, USA
  • Diego G Diel; Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, New York
Preprint em Inglês | bioRxiv | ID: ppbiorxiv-213959
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ABSTRACT
We describe the first cases of natural SARS-CoV-2 infection detected in animals in the United States. In March 2020, four tigers and three lions at the Bronx Zoo developed mild respiratory signs. SARS-CoV-2 RNA was detected by rRT-PCR in respiratory secretions and/or feces from all seven affected animals; viral RNA and/or antibodies were detected in their keepers. SARS-CoV-2 was isolated from respiratory secretions or feces from three affected animals; in situ hybridization co-localized viral RNA with cellular damage. Whole genome sequence and haplotype network analyses showed tigers and lions were infected with two different SARS-CoV-2 strains, suggesting independent viral introductions. The source of SARS-CoV-2 infection in the lions is unknown. Epidemiological data and genetic similarities between keeper and tiger viruses indicate human to animal transmission.
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Texto completo: Disponível Coleções: Preprints Base de dados: bioRxiv Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Preprint
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: Disponível Coleções: Preprints Base de dados: bioRxiv Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Preprint