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Genomic and phylogenetic analyses of SARS-CoV-2 strains isolated in the city of Gwangju, South Korea
Kim Min Ji; Lee Ji-eun; Chung Jae Keun; Kim Tae sun; Park Jungwook; Lim Mi hyeon; Hwang Da jeong; Jeong Jin; Yoon Ji-eun; Kee Hye young; Seo Jin jong; Kim Kwang gon.
Afiliação
  • Kim Min Ji; Health and Environmental Research Institution of Gwangju Metropolitan city
  • Lee Ji-eun; Health and Environmental Research Institution of Gwangju Metropolitan city
  • Chung Jae Keun; Health and Environmental Research Institution of Gwangju Metropolitan city
  • Kim Tae sun; Health and Environmental Research Institution of Gwangju Metropolitan city
  • Park Jungwook; Health and Environmental Research Institution of Gwangju Metropolitan city
  • Lim Mi hyeon; Health and Environmental Research Institution of Gwangju Metropolitan city
  • Hwang Da jeong; Health and Environmental Research Institution of Gwangju Metropolitan city
  • Jeong Jin; Health and Environmental Research Institution of Gwangju Metropolitan city
  • Yoon Ji-eun; Health and Environmental Research Institution of Gwangju Metropolitan city
  • Kee Hye young; Health and Environmental Research Institution of Gwangju Metropolitan city
  • Seo Jin jong; Health and Environmental Research Institution of Gwangju Metropolitan city
  • Kim Kwang gon; Health and Environmental Research Institution of Gwangju Metropolitan city
Preprint em Inglês | bioRxiv | ID: ppbiorxiv-423178
ABSTRACT
Since the first identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China in late December 2019, the coronavirus disease 2019 (COVID-19) has spread fast around the world. RNA viruses, including SARS-CoV-2, have higher gene mutations than DNA viruses during virus replication. Variations in SARS-CoV-2 genome could contribute to efficiency of viral spread and severity of COVID-19. In this study, we analyzed the locations of genomic mutations to investigate the genetic diversity among isolates of SARS-CoV-2 in Gwangju. We detected non-synonymous and frameshift mutations in various parts of SARS-CoV-2 genome. The phylogenetic analysis for whole genome showed that SARS-CoV-2 genomes in Gwangju isolates are clustered within clade V and G. Our findings not only provide a glimpse into changes of prevalent virus clades in Gwangju, South Korea, but also support genomic surveillance of SARS-CoV-2 to aid in the development of efficient therapeutic antibodies and vaccines against COVID-19.
Licença
cc_by_nc_nd
Texto completo: Disponível Coleções: Preprints Base de dados: bioRxiv Tipo de estudo: Estudo prognóstico Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: bioRxiv Tipo de estudo: Estudo prognóstico Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Preprint
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