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Human embryonic stem cell-derived cardiomyocytes express SARS-CoV-2 host entry proteins: screen to identify inhibitors of infection
Thomas L Williams; Maria T Colzani; Robyn GC Macrae; Emma L Robinson; Stuart Bloor; Edward JD Greenwood; Jun Ru Zhan; Gregory Strachan; Rhoda E Kuc; Duuamene Nyimanu; Janet J Maguire; Paul J Lehner; Sanjay Sinha; Anthony P Davenport.
Afiliação
  • Thomas L Williams; University of Cambridge
  • Maria T Colzani; University of Cambridge
  • Robyn GC Macrae; University of Cambridge
  • Emma L Robinson; University of Colorado Denver
  • Stuart Bloor; University of Cambridge
  • Edward JD Greenwood; University of Cambridge
  • Jun Ru Zhan; University of Cambridge
  • Gregory Strachan; University of Cambridge
  • Rhoda E Kuc; University of Cambridge
  • Duuamene Nyimanu; University of Cambridge
  • Janet J Maguire; University of Cambridge
  • Paul J Lehner; University of Cambridge
  • Sanjay Sinha; University of Cambridge
  • Anthony P Davenport; University of Cambridge
Preprint em Inglês | bioRxiv | ID: ppbiorxiv-427737
ABSTRACT
Patients with cardiovascular comorbidities are more susceptible to severe infection with SARS-CoV-2, known to directly cause pathological damage to cardiovascular tissue. We outline a screening platform using human embryonic stem cell-derived cardiomyocytes, confirmed to express the protein machinery critical for SARS-CoV-2 infection, and a pseudotyped virus system. The method has allowed us to identify benztropine and DX600 as novel inhibitors of SARS-CoV-2 infection.
Licença
cc_no
Texto completo: Disponível Coleções: Preprints Base de dados: bioRxiv Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: bioRxiv Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
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