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Occurrence of COVID-19 symptoms during SARS-CoV-2 infection defines waning of humoral immunity
Jun Wu; Boyun Liang; Yaohui Fang; Hua Wang; Xiaoli Yang; Shu Shen; Liangkai Chen; Sumeng Li; Sihong Lu; Tiandan Xiang; Jia Liu; Vu Thuy Khanh Le-Trilling; Mengji Lu; Dongliang Yang; Fei Deng; Ulf Dittmer; Mirko Trilling; Xin Zheng.
Afiliação
  • Jun Wu; Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Wuhan 430022, China
  • Boyun Liang; Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Wuhan 430022, China
  • Yaohui Fang; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences; Wuhan 430071, China
  • Hua Wang; Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Wuhan 430022, China
  • Xiaoli Yang; Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Wuhan 430022, China
  • Shu Shen; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences; Wuhan 430071, China
  • Liangkai Chen; Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology; Wuhan 4
  • Sumeng Li; Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Wuhan 430022, China
  • Sihong Lu; Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Wuhan 430022, China
  • Tiandan Xiang; Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Wuhan 430022, China
  • Jia Liu; Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Wuhan 430022, China
  • Vu Thuy Khanh Le-Trilling; Institute for Virology, University Hospital of Essen, University of Duisburg-Essen; Essen 45147, Germany
  • Mengji Lu; Institute for Virology, University Hospital of Essen, University of Duisburg-Essen; Essen 45147, Germany
  • Dongliang Yang; Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Wuhan 430022, China
  • Fei Deng; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences; Wuhan 430071, China
  • Ulf Dittmer; Institute for Virology, University Hospital of Essen, University of Duisburg-Essen; Essen 45147, Germany
  • Mirko Trilling; Institute for Virology, University Hospital of Essen, University of Duisburg-Essen; Essen 45147, Germany
  • Xin Zheng; Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Wuhan 430022, China
Preprint em Inglês | bioRxiv | ID: ppbiorxiv-437123
ABSTRACT
Approximately half of the SARS-CoV-2 infections occur without apparent symptoms, raising questions regarding long-term humoral immunity in asymptomatic individuals. Plasma levels of immunoglobulin G (IgG) and M (IgM) against the viral spike or nucleoprotein were determined for 25,091 individuals enrolled in a surveillance program in Wuhan, China. We compared 405 asymptomatic individuals with 459 symptomatic COVID-19 patients. The well-defined duration of the SARS-CoV-2 endemic in Wuhan allowed a side-by-side comparison of antibody responses following symptomatic and asymptomatic infections without subsequent antigen re-exposure. IgM responses rapidly declined in both groups. However, both the prevalence and durability of IgG responses and neutralizing capacities correlated positively with symptoms. Regardless of sex, age, and body weight, asymptomatic individuals lost their SARS-CoV-2-specific IgG antibodies more often and rapidly than symptomatic patients. These findings have important implications for immunity and favour immunization programs including individuals after asymptomatic infections. One-Sentence SummaryPrevalence and durability of SARS-CoV-2-specific IgG responses and neutralizing capacities correlate with COVID-19 symptoms.
Licença
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Texto completo: Disponível Coleções: Preprints Base de dados: bioRxiv Tipo de estudo: Experimental_studies / Estudo observacional / Rct Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: bioRxiv Tipo de estudo: Experimental_studies / Estudo observacional / Rct Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
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