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Neutralization potential of Covishield vaccinated individuals against B.1.617.1
Pragya Yadav; Gajanan N Sapkal; Priya Abraham; Gururaj Deshpande; Dimpal Nyayanit; Deepak Y Patil; Nivedita Gupta; Rima R Sahay; Anita Shete; Sanjay Kumar; Samiran Panda; Balram Bhargava.
Afiliação
  • Pragya Yadav; ICMR-National Institute of Virology
  • Gajanan N Sapkal; ICMR-National Institute of Virology
  • Priya Abraham; Indian Council of Medical Research-National Institute of Virology, Pune, India
  • Gururaj Deshpande; Indian Council of Medical Research-National Institute of Virology, Pune, India
  • Dimpal Nyayanit; Indian Council of Medical Research-National Institute of Virology, Pune, India
  • Deepak Y Patil; Indian Council of Medical Research-National Institute of Virology, Pune, India
  • Nivedita Gupta; Indian Council of Medical Research, V. Ramalingaswami Bhawan, Ansari Nagar, New Delhi, India
  • Rima R Sahay; Indian Council of Medical Research-National Institute of Virology, Pune, India
  • Anita Shete; Indian Council of Medical Research-National Institute of Virology, Pune, India
  • Sanjay Kumar; Department of Neurosurgery, Command Hospital (Southern Command), Armed Forces Medical College (AFMC), Pune, Maharashtra, India
  • Samiran Panda; Indian Council of Medical Research, V. Ramalingaswami Bhawan, Ansari Nagar, New Delhi, India
  • Balram Bhargava; Indian Council of Medical Research, V. Ramalingaswami Bhawan, Ansari Nagar, New Delhi, India
Preprint em Inglês | bioRxiv | ID: ppbiorxiv-443645
ABSTRACT
Covishield comprises the larger proportion in the vaccination program in India. Hence, it is of utmost importance to understand neutralizing capability of vaccine against the B.1.617.1 variant which is considered to responsible for surge of the cases in India. The neutralizing-antibody (NAb) titer against B.1.167.1 and prototype B.1 variant (D614G) was determined of the vaccine sera (4 weeks after second dose) of COVID-19 naive subjects (n=43) and COVID-19 recovered subjects (n=18). The results demonstrated that sera of COVID-19 recovered subjects (n=18) who received two doses of Covishield have higher NAb response compared to the COVID-19 naive with a significant difference (p<0.0001) in NAb titer against B.1 and B.1.617.1 In-spite of reduction in the neutralizing titer against B.1.617.1 variant; Covishield vaccine-induced antibodies are likely to be protective to limit the severity and mortality of the disease in the vaccinated individuals.
Licença
cc_by_nc_nd
Texto completo: Disponível Coleções: Preprints Base de dados: bioRxiv Tipo de estudo: Estudo prognóstico Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: bioRxiv Tipo de estudo: Estudo prognóstico Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
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