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Immunological features that determine the strength of antibody responses to BNT162b2 mRNA vaccine against SARS-CoV-2
Takahiro Kageyama; Shigeru Tanaka; Keishi Etori; Koto Hattori; Kazusa Miyachi; Tadamichi Kasuya; Taro Iwamoto; Kei Ikeda; Hidetoshi Igari; Koutaro Yokote; Hiroshi Nakajima.
Afiliação
  • Takahiro Kageyama; Chiba University
  • Shigeru Tanaka; Chiba University
  • Keishi Etori; Chiba University
  • Koto Hattori; Chiba University
  • Kazusa Miyachi; Chiba University
  • Tadamichi Kasuya; Chiba University
  • Taro Iwamoto; Chiba University
  • Kei Ikeda; Chiba University
  • Hidetoshi Igari; Chiba University
  • Koutaro Yokote; Chiba University
  • Hiroshi Nakajima; Chiba University
Preprint em Inglês | bioRxiv | ID: ppbiorxiv-449182
ABSTRACT
We analyzed peripheral blood mononuclear cells (PBMCs) of each 20 individuals with a high anti-SARS-CoV-2 antibody titer and a low antibody titer out of 1,774 healthcare workers who received BNT162b2 mRNA vaccine. A higher antibody titer was associated with the frequencies of naive and transitional B cells before vaccination. In addition, fold changes in the frequency of activated CD8+ T cells upon vaccination were correlated with the antibody titers.
Licença
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Texto completo: Disponível Coleções: Preprints Base de dados: bioRxiv Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: bioRxiv Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
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