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Regional Variant Analysis of Spike Glycoprotein Mutations of SARS-CoV-2 and Its Implications in COVID-19 Pandemic Control
Naseef Punnoth Poonkuzhi; Muhammed Elayadeth-Meethal; Shyju Ollakkot; Ilyas UK; Mohamed Saheer Kuruniyan.
Afiliação
  • Naseef Punnoth Poonkuzhi; Moulana College of Pharmacy
  • Muhammed Elayadeth-Meethal; Kerala Veterinary and Animal Sciences University
  • Shyju Ollakkot; Kerala Veterinary and Animal Sciences University
  • Ilyas UK; Department of Pharmacognosy and Phytochemistry, SRF, Faculty of Pharmacy, Hamdard University, New Delhi, India
  • Mohamed Saheer Kuruniyan; ept. of Dental Technology. COAMS. King Khalid University. Abha. Saudi Arabia
Preprint em Inglês | bioRxiv | ID: ppbiorxiv-454771
ABSTRACT
Mutations in the spike glycoprotein have various impacts on the receptor binding, antibody interaction, and host range of SARS-CoV-2. As the interaction of spike glycoprotein with the human ACE2 receptor is the entry point of SARS-CoV-2 in human cells, mutations in the spike protein itself contain numerous impacts on the pandemic. Here, we analysed all the mutations in the spike glycoprotein from123 strains isolated from Kerala, India. We also predicted the possible structural relevance of the unique mutations based on topological analysis of the residue interaction network of the spike glycoprotein structure.
Licença
cc_by_nc_nd
Texto completo: Disponível Coleções: Preprints Base de dados: bioRxiv Tipo de estudo: Estudo prognóstico Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: bioRxiv Tipo de estudo: Estudo prognóstico Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
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