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Inducible Bronchus-Associated Lymphoid Tissue in SARS-CoV-2 Infected Rhesus Macaques
Zhong-Min Ma; Katherine J Olstad; Koen K. A. Van Rompay; Smita S. Iyer; Christopher J Miller; J. Rachel Reader.
Afiliação
  • Zhong-Min Ma; UC Davis
  • Katherine J Olstad; UC Davis
  • Koen K. A. Van Rompay; UC Davis
  • Smita S. Iyer; UC Davis
  • Christopher J Miller; UC Davis
  • J. Rachel Reader; UC Davis
Preprint em En | PREPRINT-BIORXIV | ID: ppbiorxiv-499813
ABSTRACT
Pulmonary immunity against SARS-CoV-2 infection has not been well studied. This study investigated the distribution of immune cells int the lungs of 8 rhesus macaques experimentally infected with SARS-CoV-2, and euthanized 11-14 days later. Using immunohistochemistry, inducible bronchus-associated lymphoid tissue was found in all animals. The inducible bronchus-associated lymphoid tissues were composed of B cells, T cells, and follicular dendritic cells with evidence of lymphocyte priming and differentiation. This suggests local immunity plays an important role in the SARS-CoV-2 infection. Further study of local immunity in the lung would benefit our understanding of SARS-CoV-2 pathogenesis and could lead to new interventions to control the SARS-CoV-2 infection and disease.
Licença
cc_by_nc
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-BIORXIV Idioma: En Ano de publicação: 2022 Tipo de documento: Preprint
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-BIORXIV Idioma: En Ano de publicação: 2022 Tipo de documento: Preprint