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Protection of Rhesus Macaque from SARS-Coronavirus challenge by recombinant adenovirus vaccine
Yiyou Chen; Chuan Qin; Qiang Wei; Ruobing Li; Hong Gao; Hua Zhu; Wei Deng; Linlin Bao; Tong Wei.
Afiliação
  • Yiyou Chen; New Horizon Health Ltd
  • Chuan Qin; Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences
  • Qiang Wei; Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences
  • Ruobing Li; Novartis Institute of Biomedical Research, Shanghai
  • Hong Gao; Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences
  • Hua Zhu; Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences
  • Wei Deng; Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences
  • Linlin Bao; Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences
  • Tong Wei; Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences
Preprint em Inglês | bioRxiv | ID: ppbiorxiv-951939
ABSTRACT
A recombinant adenovirus vaccine against the SARS Coronavirus (SARS-CoV) was constructed, which contains fragments from the S, N, and Orf8 genes. Rhesus Macaques immunized with the recombinant adenovirus generated antigen-specific humoral and cellular response. Furthermore, the vaccine provided significant protection against subsequent live SARS-CoV challenge. In contrast, three out of four monkeys immunized with placebo suffered severe alveolar damage and pulmonary destruction.
Licença
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Texto completo: Disponível Coleções: Preprints Base de dados: bioRxiv Tipo de estudo: Rct Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: bioRxiv Tipo de estudo: Rct Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Preprint
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