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Replication of SARS-CoV-2 in human respiratory epithelium
Aleksandra Milewska; Anna Kula-Pacurar; Jakub Wadas; Agnieszka Suder; Artur Szczepanski; Agnieszka Dabrowska; Katarzyna Owczarek; Marek Ochman; Tomasz Stacel; Zenon Rajfur; Pawel Piotr Labaj; Wojciech Branicki; Krzysztof Pyrc.
Afiliação
  • Aleksandra Milewska; Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.
  • Anna Kula-Pacurar; Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.
  • Jakub Wadas; Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.
  • Agnieszka Suder; Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.
  • Artur Szczepanski; Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.
  • Agnieszka Dabrowska; Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.
  • Katarzyna Owczarek; Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.
  • Marek Ochman; Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, the Medical University of Silesia in Katowice, Silesian Centre for Heart Diseases,
  • Tomasz Stacel; Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, the Medical University of Silesia in Katowice, Silesian Centre for Heart Diseases,
  • Zenon Rajfur; Institute of Physics, Faculty of Physics, Astronomy and Applied Computer Sciences, Jagiellonian University, Lojasiewicza 11, 30-348, Krakow, Poland.
  • Pawel Piotr Labaj; Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.
  • Wojciech Branicki; Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.
  • Krzysztof Pyrc; Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Krakow, Poland.
Preprint em Inglês | bioRxiv | ID: ppbiorxiv-999029
ABSTRACT
SARS-CoV-2 emerged by the end of 2019 to rapidly spread in 2020. At present, it is of utmost importance to understand the virus biology and to rapidly assess the potential of existing drugs and develop new active compounds. While some animal models for such studies are under development, most of the research is carried out in the Vero E6 cells. Here, we propose fully differentiated human airway epithelium cultures as a model for studies on the SARS-CoV-2. Further, we also provide basic characteristics of the system.
Licença
cc_no
Texto completo: Disponível Coleções: Preprints Base de dados: bioRxiv Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: bioRxiv Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Preprint
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