Your browser doesn't support javascript.
loading
The impact of changes in diagnostic testing practices on estimates of COVID-19 transmission in the United States
Virginia E. Pitzer; Melanie Chitwood; Joshua Havumaki; Nicolas A. Menzies; Stephanie Perniciaro; Joshua L. Warren; Daniel M. Weinberger; Ted Cohen.
Afiliação
  • Virginia E. Pitzer; Yale School of Public Health
  • Melanie Chitwood; Yale School of Public Health
  • Joshua Havumaki; Yale School of Public Health
  • Nicolas A. Menzies; Harvard T.H. Chan School of Public Health
  • Stephanie Perniciaro; Yale School of Public Health
  • Joshua L. Warren; Yale School of Public Health
  • Daniel M. Weinberger; Yale School of Public Health
  • Ted Cohen; Yale School of Public Health
Preprint em En | PREPRINT-MEDRXIV | ID: ppmedrxiv-20073338
Artigo de periódico
Um artigo publicado em periódico científico está disponível e provavelmente é baseado neste preprint, por meio do reconhecimento de similaridade realizado por uma máquina. A confirmação humana ainda está pendente.
Ver artigo de periódico
ABSTRACT
Estimates of the reproductive number for novel pathogens such as SARS-CoV-2 are essential for understanding the potential trajectory of the epidemic and the level of intervention that is needed to bring the epidemic under control. However, most methods for estimating the basic reproductive number (R0) and time-varying effective reproductive number (Rt) assume that the fraction of cases detected and reported is constant through time. We explore the impact of secular changes in diagnostic testing and reporting on estimates of R0 and Rt using simulated data. We then compare these patterns to data on reported cases of COVID-19 and testing practices from different United States (US) states. We find that changes in testing practices and delays in reporting can result in biased estimates of R0 and Rt. Examination of changes in the daily number of tests conducted and the percent of patients testing positive may be helpful for identifying the potential direction of bias. Changes in diagnostic testing and reporting processes should be monitored and taken into consideration when interpreting estimates of the reproductive number of COVID-19.
Licença
cc_by
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Diagnostic_studies / Experimental_studies / Observational_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Preprint
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Diagnostic_studies / Experimental_studies / Observational_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Preprint