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Pulmonary alveolar regrowth in an adult COVID-19 patient
Jingyu Chen; Huijuan Wu; Yuanyuan Yu; Nan Tang.
Afiliação
  • Jingyu Chen; Wuxi Lung Transplantation Center, Wuxi People Hospital affiliated to Nanjing Medical University,
  • Huijuan Wu; School of Life Sciences, Tsinghua University, National Institute of Biological Sciences, Beijing
  • Yuanyuan Yu; School of Life Sciences, Tsinghua University, National Institute of Biological Sciences, Beijing
  • Nan Tang; National Institute of Biological Sciences, Beijing
Preprint em Inglês | medRxiv | ID: ppmedrxiv-20097634
ABSTRACT
We detected active alveolar regrowth in the lung of a 58-year-old COVID-19 patient who underwent lung transplantation due to severe lung hemorrhage. Specifically, immunohistological and scanning electronic microscopy analyses revealed that alveolar type II epithelial cells (AT2 cells) accumulate in response to viral pneumonia and that these AT2 cells actively proliferate and differentiate into squamous AT1-like alveolar epithelial cells. Thus, our work establishes that alveolar regrowth does occur in post-COVID-19 injury adult human lungs.
Licença
cc_by_nc_nd
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Preprint
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