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A phenome-wide association study (PheWAS) of COVID-19 outcomes by race using the electronic health records data in Michigan Medicine
Maxwell Salvatore; Tian Gu; Jasmine A. Mack; Swaraaj Prabhu Sankar; Snehal Patil; Thomas S. Valley; Karandeep Singh; Brahmajee K. Nallamothu; Sachin Kheterpal; Lynda Lisabeth; Lars G. Fritsche; Bhramar Mukherjee.
Afiliação
  • Maxwell Salvatore; Department of Biostatistics, University of Michigan
  • Tian Gu; Department of Biostatistics, University of Michigan
  • Jasmine A. Mack; Department of Biostatistics, University of Michigan
  • Swaraaj Prabhu Sankar; Data Office for Clinical and Translational Research, University of Michigan
  • Snehal Patil; Precision Health, University of Michigan
  • Thomas S. Valley; University of Michigan Medical School
  • Karandeep Singh; University of Michigan Medical School
  • Brahmajee K. Nallamothu; University of Michigan Medical School
  • Sachin Kheterpal; University of Michigan Medical School
  • Lynda Lisabeth; Department of Epidemiology, School of Public Health, University of Michigan
  • Lars G. Fritsche; University of Michigan
  • Bhramar Mukherjee; University of Michigan
Preprint em Inglês | medRxiv | ID: ppmedrxiv-20141564
Artigo de periódico
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ABSTRACT
BackgroundWe perform a phenome-wide scan to identify pre-existing conditions related to COVID-19 susceptibility and prognosis across the medical phenome and how they vary by race. MethodsThe study is comprised of 53,853 patients who were tested/positive for COVID-19 between March 10 and September 2, 2020 at a large academic medical center. ResultsPre-existing conditions strongly associated with hospitalization were renal failure, pulmonary heart disease, and respiratory failure. Hematopoietic conditions were associated with ICU admission/mortality and mental disorders were associated with mortality in non-Hispanic Whites. Circulatory system and genitourinary conditions were associated with ICU admission/mortality in non-Hispanic Blacks. ConclusionsUnderstanding pre-existing clinical diagnoses related to COVID-19 outcomes informs the need for targeted screening to support specific vulnerable populations to improve disease prevention and healthcare delivery.
Licença
cc_by_nc_nd
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Estudo prognóstico Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Estudo prognóstico Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Preprint
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