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Seroconversion of a city: Longitudinal monitoring of SARS-CoV-2 seroprevalence in New York City
Daniel Stadlbauer; Jessica Tan; Kaijun Jiang; Matthew Hernandez; Shelcie Fabre; Fatima Amanat; Catherine Teo; Guh Asthagiri Arunkumar; Meagan McMahon; Jeffrey Jhang; Michael Nowak; Viviana Simon; Emilia Sordillo; Harm van Bakel; Florian Krammer.
Afiliação
  • Daniel Stadlbauer; Icahn School of Medicine at Mount Sinai
  • Jessica Tan; Icahn School of Medicine at Mount Sinai
  • Kaijun Jiang; Icahn School of Medicine at Mount Sinai
  • Matthew Hernandez; Icahn School of Medicine at Mount Sinai
  • Shelcie Fabre; Mount Sinai Hospital
  • Fatima Amanat; Icahn School of Medicine at Mount Sinai
  • Catherine Teo; Icahn School of Medicine at Mount Sinai
  • Guh Asthagiri Arunkumar; Icahn School of Medicine at Mount Sinai
  • Meagan McMahon; Icahn School of Medicine at Mount Sinai
  • Jeffrey Jhang; Mount Sinai Hospital
  • Michael Nowak; Mount Sinai Hospital
  • Viviana Simon; Icahn School of Medicine
  • Emilia Sordillo; Mount Sinai Hospital
  • Harm van Bakel; Icahn School of Medicine at Mount Sinai
  • Florian Krammer; Icahn School of Medicine at Mount Sinai
Preprint em Inglês | medRxiv | ID: ppmedrxiv-20142190
ABSTRACT
By conducting a retrospective, cross-sectional analysis of SARS-CoV-2 seroprevalence in a sentinel group (enriched for SARS-CoV-2 infections) and a screening group (representative of the general population) using >5,000 plasma samples from patients at Mount Sinai Hospital in New York City (NYC), we identified seropositive samples as early as in the week ending February 23, 2020. A stark increase in seropositivity in the sentinel group started the week ending March 22 and in the screening group in the week ending March 29. By the week ending April 19, the seroprevalence in the screening group reached 19.3%, which is well below the estimated 67% needed to achieve community immunity to SARS-CoV-2. These data potentially suggest an earlier than previously documented introduction of SARS-CoV-2 into the NYC metropolitan area. One Sentence SummarySeroprevalence of SARS-CoV-2 in cross-sectional samples from New York City rose from 0% to 19.3% from early February to mid-April.
Licença
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Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Estudo observacional / Estudo prognóstico / Rct Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Estudo observacional / Estudo prognóstico / Rct Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Preprint
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