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SARS-CoV-2 Seroprevalence Rates of Children in Louisiana During the State Stay at Home Order.
Monika L Dietrich; Elizabeth B Norton; Debra Elliott; Ashley R Smira; Julie A Rouelle; Nell G Bond; Karen Aime-Marcelin; Alisha Prystowsky; Rebecca Kemnitz; Arunava Sarma; Sarah Talia Himmelfarb; Neha Sharma; Addison E Stone; Randall Craver; Alyssa R Lindrose; Leslie A Smitley; Robert B Uddo; Leann Myers; Stacy S Drury; John S Schieffelin; James E Robinson; Kevin J Zwezdaryk.
Afiliação
  • Monika L Dietrich; Department of Pediatrics, Tulane University, New Orleans, LA, USA
  • Elizabeth B Norton; Department of Microbiology and Immunology, Tulane University, New Orleans, LA, USA
  • Debra Elliott; Tulane University
  • Ashley R Smira; Tulane University
  • Julie A Rouelle; Tulane University
  • Nell G Bond; Department of Pediatrics, Tulane University, New Orleans, LA, USA
  • Karen Aime-Marcelin; Department of Pediatrics, Tulane University, New Orleans, LA, USA
  • Alisha Prystowsky; Department of Pediatrics, Tulane University, New Orleans, LA, USA
  • Rebecca Kemnitz; Department of Pediatrics, Tulane University, New Orleans, LA, USA
  • Arunava Sarma; Department of Pediatrics, Tulane University, New Orleans, LA, USA
  • Sarah Talia Himmelfarb; Internal Medicine and Pediatrics, Tulane University, New Orleans, LA USA
  • Neha Sharma; Department of Pediatrics, Tulane University, New Orleans, LA, USA
  • Addison E Stone; Department of Microbiology and Immunology, Tulane University, New Orleans, LA, USA
  • Randall Craver; Childrens Hospital of New Orleans, New Orleans, LA USA
  • Alyssa R Lindrose; Department of Psychiatry and Behavioral Sciences, Tulane University, LA USA
  • Leslie A Smitley; Department of Pediatrics, Tulane University, New Orleans, LA, USA
  • Robert B Uddo; Childrens Hospital of New Orleans, New Orleans, LA USA
  • Leann Myers; Department of Biostatistics & Data Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA
  • Stacy S Drury; Department of Pediatrics, Tulane University, New Orleans, LA, USA, Department of Psychiatry and Behavioral Sciences, Tulane University, LA USA
  • John S Schieffelin; Department of Pediatrics, Tulane University, New Orleans, LA, USA
  • James E Robinson; Department of Pediatrics, Tulane University, New Orleans, LA, USA
  • Kevin J Zwezdaryk; Department of Microbiology and Immunology, Tulane University, New Orleans, LA, USA
Preprint em Inglês | medRxiv | ID: ppmedrxiv-20147884
ABSTRACT
BACKGROUNDChildren ([≤]18 years) account for [~]20% of the US population but currently represent <2% of coronavirus disease 2019 (COVID-19) cases. Because infected children often have few or no symptoms and may not be tested, the extent of infection in children is poorly understood. METHODSDuring the March 18th-May 15th 2020 Louisiana Stay At Home Order, 1690 blood samples from 812 individuals from a Childrens Hospital were tested for antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. Demographics, COVID-19 testing, and clinical presentation abstracted from medical records were compared with local COVID-19 cases. RESULTSIn total, 62 subjects (7.6%) were found to be seropositive. The median age was 11 years with 50.4% female. The presenting complaint of seropositive patients was chronic illness (43.5%). Only 18.2% had a previous positive COVID-19 PCR or antibody test. Seropositivity was significantly associated with parish (counties), race, and residence in a low-income area. Importantly, seropositivity was linearly correlated with cumulative COVID-19 case number for all ages by parish. CONCLUSIONIn a large retrospective study, the seropositivity prevalence for SARS-CoV-2 in children in Louisiana during the mandated Stay At Home Order was 7.6%. Residence location, race, and lower socioeconomic factors were linked to more frequent seropositivity in children and correlated to regional COVID-19 case rates. Thus, a significant number of children in Louisiana had SARS-CoV-2 infections that went undetected and unreported and may have contributed to virus transmission.
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Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Estudo observacional / Estudo prognóstico Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Preprint
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Estudo observacional / Estudo prognóstico Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Preprint