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Prevalence of amyloid blood clots in COVID-19 plasma
Etheresia Pretorius; Chantelle Venter; Gert J Laubscher; Petrus J Lourens; Janami Steenkamp; Douglas B Kell.
Afiliação
  • Etheresia Pretorius; Stellenbosch University
  • Chantelle Venter; Stellenbosch University
  • Gert J Laubscher; Stellenbosch MediClinic Private Practice
  • Petrus J Lourens; Stellenbosch MediClinic Private Practice
  • Janami Steenkamp; PathCare Laboratories
  • Douglas B Kell; University of Liverpool
Preprint em En | PREPRINT-MEDRXIV | ID: ppmedrxiv-20163543
ABSTRACT
The rapid detection of COVID-19 uses genotypic testing for the presence of SARS-Cov-2 virus in nasopharyngeal swabs, but it can have a poor sensitivity. A rapid, host-based physiological test that indicated whether the individual was infected or not would be highly desirable. Coagulaopathies are a common accompaniment to COVID-19, especially micro-clots within the lungs. We show here that microclots can be detected in the native plasma of COVID-19 patient, and in particular that such clots are amyloid in nature as judged by a standard fluorogenic stain. This provides a rapid and convenient test (P<0.0001), and suggests that the early detection and prevention of such clotting could have an important role in therapy.
Licença
cc_by
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Diagnostic_studies / Observational_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Preprint
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Diagnostic_studies / Observational_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Preprint