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Respiratory viral infections by Non-influenza viruses are associated with more adverse clinical outcome in patients with underlying liver disease: a single centre laboratory based study.
Ekta Gupta; Abhishek Padhi; Kavita Agarwal; Krithiga Ramachandran; Reshu Aggarwal; Samba Siva Rao Pasupuleti; Debajyoti Bhattacharyya; Rakhi Maiwall; Shiv Kumar Sarin.
Afiliação
  • Ekta Gupta; ILBS
  • Abhishek Padhi; ILBS
  • Kavita Agarwal; ILBS
  • Krithiga Ramachandran; Institute of Liver and Biliary Sciences
  • Reshu Aggarwal; Institute of Liver and Biliary Sciences
  • Samba Siva Rao Pasupuleti; ILBS
  • Debajyoti Bhattacharyya; INSTITUTE OF LIVER & BILIARY SCIENCES, NEW DELHI
  • Rakhi Maiwall; ILBS
  • Shiv Kumar Sarin; Institute of Liver and Biliary Sciences (ILBS)
Preprint em Inglês | medRxiv | ID: ppmedrxiv-20166330
ABSTRACT
BackgroundRespiratory viral infections are an important cause of acute respiratory tract infections. They are caused by both Influenza and non influenza viruses. Respiratory viral infections are known to be associated with severe clinical outcome especially in the critically ill. A constant surveillance is needed for early etiological identification which can help in timely and appropriate management and will further help in prevention of indiscriminate use of antibiotics in patients with viral etiology. MethodsIn this retrospective study, clinical records of all adult liver disease patients with clinically confirmed ARI, whose request for respiratory viral testing were received in the virology laboratory during September 2016 - March 2019 were reviewed. Respiratory viruses were identified by real time PCR on FilmArray 2.0 instrument (BioFire Diagnostics, Utah, USA) using Respiratory panel as per the manufacturers instructions. ResultsOf the 603 patients of liver disease with clinically confirmed influenza like illness, over all incidence of respiratory viral infection was 24.3% (n= 147). Infections by non-influenza viruses (87, 59.1%) were more than influenza group of viruses. Mortality was higher in non influenza group (43, 49.4%) as compared to influenza (24, 40%) [p=0.015] being maximum in Rhinovirus, 22 (32.8%). Two peaks were observed in both influenza and non influenza groups, first in the months of January and February and the other one in August and October. ConclusionWith the emergence of SARS-CoV-2 it has now become imperative for a constant surveillance of the non influenza viruses for early etiological identification of the respiratory viral infection for proper and timely management in the critically ill. HighlightsO_LIPatients with liver cirrhosis having Respiratory viral infections have a poor outcome in terms of morbidity and mortality. C_LIO_LIMortality associated with non influenza viruses (NIV) is more as compared to influenza virus infections. C_LIO_LICOVID-19 pandemic and higher mortality in NIVs warrants a constant monitoring of respiratory viral infections. C_LI
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Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Estudo de etiologia / Experimental_studies / Estudo observacional / Estudo prognóstico / Rct Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Estudo de etiologia / Experimental_studies / Estudo observacional / Estudo prognóstico / Rct Idioma: Inglês Ano de publicação: 2020 Tipo de documento: Preprint
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