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Evaluation of the comparative risk of aerosol generation by tracheal intubation and extubation in the operating theatre
Preprint
em Inglês
| medRxiv
| ID: ppmedrxiv-20180067
ABSTRACT
BackgroundTransmission of SARS-CoV-2 by bioaerosols is of increasing concern. The enhanced levels of personal protective equipment (PPE) and preventative measures to attenuate viral transmission during aerosol generating procedures (AGPs) are having a huge impact on healthcare provision. There is no quantitative evidence on the number and size of airborne particles produced during AGPs to inform risk assessments. MethodsReal-time, high-resolution environmental monitoring was conducted in ultraclean ventilation operating theatres. Continuous sampling with an optical particle sizer allowed characterization of aerosol generation within the airway management zone during endotracheal intubation and extubation for urgent orthopaedic trauma or neuro-surgery. ResultsAerosol monitoring showed a very low background particle count allowing resolution of the transient airborne particle plume produced by reference volitional coughs (maximum concentration, 1,690{+/-}140 particles.L-1,n=38). By comparison, endotracheal intubation including mask ventilation produced negligible quantities of aerosolized particles (maximum concentration, 80{+/-}10 L-1,n=14, P<0{middle dot}001 vs cough). Extubation, particularly when the patient coughed, produced a detectable aerosol plume but with a smaller number of particles (<25%) than a volitional cough. ConclusionsUsing a volitional cough as a reference we have been able to produce a relative risk ranking for endotracheal intubation and extubation as potential AGPs. The study does not support the assignation of endotracheal intubation by direct laryngoscopy with manual ventilation as an AGP. Extubation does generate aerosols, particularly if the patient coughs, but these are weaker than a standard reference. These findings indicate the need for a reappraisal of guidance on PPE for AGPs.
cc_by_nc_nd
Texto completo:
Disponível
Coleções:
Preprints
Base de dados:
medRxiv
Tipo de estudo:
Experimental_studies
/
Estudo prognóstico
Idioma:
Inglês
Ano de publicação:
2020
Tipo de documento:
Preprint