A chest-CT and clinical chemistry based flowchart for rapid COVID-19 triage at emergency departments - a multicenter study

ABSTRACT

BackgroundDue to the large number of patients with coronavirus disease 19 (COVID-19), rapid diagnosis at the emergency department (ED) is of critical importance. In this study we have developed a flowchart based on two well-known diagnostic methods: the corona-score and the CO-RADS. This flowchart can be used in hospitals that use chest-CT, instead of chest X-ray, for COVID-19 suspected patients at the ED. MethodsED patients (n=1904) from the Jeroen Bosch Hospital, Amphia Hospital, HagaHospital, Elisabeth TweeSteden Hospital, Bernhoven Hospital and Slingeland Hospital were included. A laboratory-based corona-score, without radiology, called the lab-corona-score was combined with a chest-CT based radiology scoring system (CO-RADS), to develop a flowchart. The performance was assessed by sensitivity/specificity analyses using the RT-PCR outcome or the physicians final diagnosis as golden standard. ResultsOut of the 1904 patients, 611 (32.1%) patients tested positive for the SARS-CoV-2 virus. The lab-corona-score alone had an AUC of 0.86, a sensitivity of 87% and a specificity of 88% using cut-off values of 0-2 (negative) and 8-10 (positive). Of 255 patients, from the Amphia and Slingeland Hospitals, a CO-RADS score was determined. The flowchart, which combined the CO-RADS with the lab-corona-score, was developed based on data from Slingeland Hospital (sensitivity 97%, specificity 96%). Hereafter, the performance of the flowchart was validated using an independent dataset from Amphia hospital, and reached a sensitivity of 98% and specificity of 93%. A decision could be made in 79% of the patients, which was correct in 95% of the cases. ConclusionThis flowchart, based on radiology (CO-RADS) and clinical chemistry parameters (lab-corona-score), results in a rapid and accurate diagnosis of COVID-19 at the ED.