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Elevated mucosal antibody responses against SARS-CoV-2 are correlated with lower viral load and faster decrease in systemic COVID-19 symptoms
Janeri Fröberg; Joshua Gillard; Ria Philipsen; Kjerstin Lanke; Joyce Rust; Diana van Tuijl; Teun Bousema; Elles Simonetti; Christa van der Gaast-de Jongh; Mariska Bos; Frank J.M. van Kuppeveld; Berend Jan Bosch; Marrigje Nabuurs-Franssen; Nannet van der Geest-Blankert; Charlotte van Daal; Martijn A. Huynen; Marien I. de Jonge; Dimitri A Diavatopoulos.
Afiliação
  • Janeri Fröberg; Radboud university medical center, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases, Nijm
  • Joshua Gillard; Centre for molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre Nijmegen, 6525 GA Nijmegen,
  • Ria Philipsen; RTC CS Radboud Technology Center Clinical Studies, Radboudumc, Nijmegen
  • Kjerstin Lanke; Radboud Center for Infectious Diseases, Radboudumc, Nijmegen
  • Joyce Rust; RTC CS Radboud Technology Center Clinical Studies, Radboudumc, Nijmegen
  • Diana van Tuijl; RTC CS Radboud Technology Center Clinical Studies, Radboudumc, Nijmegen
  • Teun Bousema; Radboud Center for Infectious Diseases, Radboudumc, Nijmegen
  • Elles Simonetti; Radboud university medical center, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases, Nijm
  • Christa van der Gaast-de Jongh; Radboud university medical center, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases, Nijm
  • Mariska Bos; Radboud university medical center, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases, Nijm
  • Frank J.M. van Kuppeveld; Utrecht University, Faculty of Veterinary Medicine, Department of Biomolecular Health Sciences, Division Infectious Diseases and Immunology, Utrecht, the Nether
  • Berend Jan Bosch; Utrecht University
  • Marrigje Nabuurs-Franssen; Department of medical microbiology and infectious diseases, Canisius Wilhelmina hospital, Nijmegen
  • Nannet van der Geest-Blankert; Department of Occupational Health, Radboud university medical centre
  • Charlotte van Daal; Department of Occupational Health, Radboud university medical centre
  • Martijn A. Huynen; Centre for molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre Nijmegen
  • Marien I. de Jonge; Radboud university medical center, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases, Nijm
  • Dimitri A Diavatopoulos; Radboud university medical center, Radboud Institute for Molecular Life Sciences, Laboratory of Medical Immunology, Section Paediatric Infectious Diseases, Nijm
Preprint em En | PREPRINT-MEDRXIV | ID: ppmedrxiv-21250910
ABSTRACT
Mucosal antibodies play a key role in protection against SARS-CoV-2 exposure, but their role during primary infection is not well understood. We assessed mucosal antibody responses during primary infection with SARS-CoV-2 and examined their relationship with viral load and clinical symptoms. Elevated mucosal IgM was associated with lower viral load. RBD and viral spike protein-specific mucosal antibodies were correlated with decreases in systemic symptoms, while older age was associated with an increase in respiratory symptoms. Up to 42% of household contacts developed SARS-CoV-2-specific mucosal antibodies, including children, indicating high transmission rates within households in which children might play an important role.
Licença
cc_by_nc_nd
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Preprint