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Seroprevalence of Antibodies to SARS-CoV-2 among Health Care Workers in Kenya
Anthony O. Etyang; Ruth Lucinde; Henry Karanja; Catherine Kalu; Daisy Mugo; James Nyagwange; John Gitonga; James Tuju; Perpetual Wanjiku; Angela Karani; Shadrack Mutua; Hosea Maroko; Eddy Nzomo; Eric Maitha; Evanson Kamuri; Thuranira Kaugiria; Justus Weru; Lucy B. Ochola; Nelson Kilimo; Sande Charo; Namdala Emukule; Wycliffe Moracha; David Mukabi; Rosemary Okuku; Monicah Ogutu; Barrack Angujo; Mark Otiende; Christian Bottomley; Edward Otieno; Leonard Ndwiga; Amek Nyaguara; Shirine Voller; Charles Agoti; David James Nokes; Lynette Isabella Ochola-Oyier; Rashid Aman; Patrick Amoth; Mercy Mwangangi; Kadondi Kasera; Wangari Nganga; Ifedayo Adetifa; Wangeci Kagucia; Katherine Gallagher; Sophie Uyoga; Benjamin Tsofa; Edwine Barasa; Philip Bejon; J. Anthony G. Scott; Ambrose Agweyu; George Warimwe.
Afiliação
  • Anthony O. Etyang; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • Ruth Lucinde; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • Henry Karanja; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • Catherine Kalu; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • Daisy Mugo; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • James Nyagwange; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • John Gitonga; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • James Tuju; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • Perpetual Wanjiku; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • Angela Karani; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • Shadrack Mutua; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • Hosea Maroko; KEMRI Center for Infectious and Parasitic Diseases Control Research
  • Eddy Nzomo; Kilifi County Hospital
  • Eric Maitha; Department of Health, Kilifi County
  • Evanson Kamuri; Kenyatta National Hospital
  • Thuranira Kaugiria; Kenyatta National Hospital
  • Justus Weru; Kenyatta National Hospital
  • Lucy B. Ochola; Institute of Primate Research
  • Nelson Kilimo; Alupe Sub-County Hospital
  • Sande Charo; Kocholia sub-County Hospital
  • Namdala Emukule; Busia County Referral Hospital
  • Wycliffe Moracha; Department of Health, Busia County
  • David Mukabi; Department of Health, Busia County
  • Rosemary Okuku; Department of Health, Busia County
  • Monicah Ogutu; Department of Health, Busia County
  • Barrack Angujo; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • Mark Otiende; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • Christian Bottomley; London School of Hygiene and Tropical Medicine
  • Edward Otieno; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • Leonard Ndwiga; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • Amek Nyaguara; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • Shirine Voller; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • Charles Agoti; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • David James Nokes; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • Lynette Isabella Ochola-Oyier; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • Rashid Aman; Ministry of Health, Government of Kenya
  • Patrick Amoth; Ministry of Health, Government of Kenya
  • Mercy Mwangangi; Ministry of Health, Government of Kenya
  • Kadondi Kasera; Ministry of Health, Government of Kenya
  • Wangari Nganga; Ministry of Health, Government of Kenya
  • Ifedayo Adetifa; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • Wangeci Kagucia; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • Katherine Gallagher; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • Sophie Uyoga; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • Benjamin Tsofa; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • Edwine Barasa; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • Philip Bejon; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • J. Anthony G. Scott; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • Ambrose Agweyu; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
  • George Warimwe; KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya
Preprint em Inglês | medRxiv | ID: ppmedrxiv-21253493
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ABSTRACT
BackgroundFew studies have assessed the seroprevalence of antibodies against SARS-CoV-2 among Health Care Workers (HCWs) in Africa. We report findings from a survey among HCWs in three counties in Kenya. MethodsWe recruited 684 HCWs from Kilifi (rural), Busia (rural) and Nairobi (urban) counties. The serosurvey was conducted between 30th July 2020 and 4th December 2020. We tested for IgG antibodies to SARS-CoV-2 spike protein using ELISA. Assay sensitivity and specificity were 93% (95% CI 88-96%) and 99% (95% CI 98-99.5%), respectively. We adjusted prevalence estimates using Bayesian modeling to account for assay performance. ResultsCrude overall seroprevalence was 19.7% (135/684). After adjustment for assay performance seroprevalence was 20.8% (95% CI 17.5-24.4%). Seroprevalence varied significantly (p<0.001) by site 43.8% (CI 35.8-52.2%) in Nairobi, 12.6% (CI 8.8-17.1%) in Busia and 11.5% (CI 7.2-17.6%) in Kilifi. In a multivariable model controlling for age, sex and site, professional cadre was not associated with differences in seroprevalence. ConclusionThese initial data demonstrate a high seroprevalence of antibodies to SARS-CoV-2 among HCWs in Kenya. There was significant variation in seroprevalence by region, but not by cadre.
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Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Estudo diagnóstico / Estudo observacional Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Estudo diagnóstico / Estudo observacional Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
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