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Quantifying the potential for dominant spread of SARS-CoV-2 variant B.1.351 in the United States
Pratha Sah; Thomas N Vilches; Affan Shoukat; Meagan C Fitzpatrick; Abhishek Pandey; Seyed M Moghadas; Alison P. Galvani.
Afiliação
  • Pratha Sah; Yale University
  • Thomas N Vilches; York University
  • Affan Shoukat; Yale University
  • Meagan C Fitzpatrick; University of Maryland
  • Abhishek Pandey; Yale University
  • Seyed M Moghadas; York University
  • Alison P. Galvani; Yale University
Preprint em Inglês | medRxiv | ID: ppmedrxiv-21256996
ABSTRACT
Recent evidence suggests that some new SARS-CoV-2 variants with spike mutations, such as P.1 (Gamma) and B.1.617.2 (Delta), exhibit partial immune evasion to antibodies generated by natural infection or vaccination. By considering the Gamma and Delta variants in a multi-variant transmission dynamic model, we evaluated the dominance of these variants in the United States (US) despite mounting vaccination coverage and other circulating variants. Our results suggest that while the dominance of the Gamma variant is improbable, the Delta variant would become the most prevalent variant in the US, driving a surge in infections and hospitalizations. Our study highlights the urgency for accelerated vaccination and continued adherence to non-pharmaceutical measures until viral circulation is driven low.
Licença
cc_by_nc_nd
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Experimental_studies Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Experimental_studies Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
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