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Durable Humoral and Cellular Immune Responses Following Ad26.COV2.S Vaccination for COVID-19
Dan H. Barouch; Kathryn Stephenson; Jerald Sadoff; Jingyou Yu; Aiquan Chang; Makda Gebre; Katherine McMahan; Jinyan Liu; Abishek Chandrashekar; Shivani Patel; Mathieu Le Gars; Anne de Groot; Dirk Heerwegh; Frank Struyf; Macaya Douoguih; Johan van Hoof; Hanneke Schuitemaker.
Afiliação
  • Dan H. Barouch; Beth Israel Deaconess Medical Center
  • Kathryn Stephenson; Beth Israel Deaconess Medical Center
  • Jerald Sadoff; Janssen Vaccines & Prevention
  • Jingyou Yu; Beth Israel Deaconess Medical Center
  • Aiquan Chang; Beth Israel Deaconess Medical Center
  • Makda Gebre; Beth Israel Deaconess Medical Center
  • Katherine McMahan; Beth Israel Deaconess Medical Center
  • Jinyan Liu; Beth Israel Deaconess Medical Center
  • Abishek Chandrashekar; Beth Israel Deaconess Medical Center
  • Shivani Patel; Beth Israel Deaconess Medical Center
  • Mathieu Le Gars; Janssen Vaccines & Prevention
  • Anne de Groot; Janssen Vaccines & Prevention
  • Dirk Heerwegh; Janssen Research & Development
  • Frank Struyf; Janssen Research & Development
  • Macaya Douoguih; Janssen Vaccines & Prevention
  • Johan van Hoof; Janssen Vaccines & Prevention
  • Hanneke Schuitemaker; Janssen Vaccines & Prevention
Preprint em En | PREPRINT-MEDRXIV | ID: ppmedrxiv-21259918
ABSTRACT
Interim immunogenicity and efficacy data for the Ad26.COV2.S vaccine for COVID-19 have recently been reported1-3. We describe here the 8-month durability of humoral and cellular immune responses in 20 individuals who received one or two doses of 5x1010 vp or 1011 vp Ad26.COV2.S and in 5 participants who received placebo2. We evaluated antibody and T cell responses on day 239, which was 8 months after the single-shot vaccine regimen (N=10) or 6 months after the two-shot vaccine regimen (N=10), although the present study was not powered to compare these regimens3. We also report neutralizing antibody responses against the parental SARS-CoV-2 WA1/2020 strain as well as against the SARS-CoV-2 variants D614G, B.1.1.7 (alpha), B.1.617.1 (kappa), B.1.617.2 (delta), P.1 (gamma), B.1.429 (epsilon), and B.1.351 (beta).
Licença
cc_by_nd
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Experimental_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo: 1 Coleções: 09-preprints Base de dados: PREPRINT-MEDRXIV Tipo de estudo: Experimental_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Preprint