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Human Milk Antibodies Elicited by BNT162b2 Vaccination Target have reduced activity against SARS-CoV-2 Variants of Concern
Jia Ming Low; Yue Gu; Melissa Shu Feng Ng; Liang Wei Wang; Amin Zubair; Youjia Zhong; Paul McAry.
Afiliação
  • Jia Ming Low; National University Hospital of Singapore
  • Yue Gu; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore
  • Melissa Shu Feng Ng; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore
  • Liang Wei Wang; Agency for Science, Technology and Research
  • Amin Zubair; Department of Neonatology, Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore
  • Youjia Zhong; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
  • Paul McAry; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore, Singapore
Preprint em Inglês | medRxiv | ID: ppmedrxiv-21263808
ABSTRACT
We detected the presence of SARS-CoV-2 specific IgA against all major VOCs in milk out to 6 weeks after D2 of BNT162b2. These likely confer some protection to the breastfed infants, who are ineligible for vaccination and are at risk of severe COVID-19. However, we detected significantly reduced milk IgA binding to VOCs, including the globally dominant Delta variant, suggesting reduced protection for breastfeeding infants. Additionally, these antibodies were significantly reduced by as early as 4-6 weeks after D2.
Licença
cc_by_nc_nd
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Estudo prognóstico Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Estudo prognóstico Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
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