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Increased risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variant compared to Alpha variant in vaccinated individuals
Stijn P. Andeweg; Harry Vennema; Irene Veldhuijzen; Naomi Smorenburg; Dennis Schmitz; Florian Zwagemaker; - SeqNeth Molecular surveillance group; - RIVM COVID-19 Molecular epidemiology group; Arianne B. van Gageldonk-Lafeber; Susan J.M. Hahne; Chantal Reusken; Mirjam J. Knol; Dirk Eggink.
Afiliação
  • Stijn P. Andeweg; National Institute for Public Health and the Environment (RIVM)
  • Harry Vennema; National Institute for Public Health and the Environment (RIVM)
  • Irene Veldhuijzen; National Institute for Public Health and the Environment (RIVM)
  • Naomi Smorenburg; National Institute for Public Health and the Environment (RIVM)
  • Dennis Schmitz; National Institute for Public Health and the Environment (RIVM)
  • Florian Zwagemaker; National Institute for Public Health and the Environment (RIVM)
  • - SeqNeth Molecular surveillance group;
  • - RIVM COVID-19 Molecular epidemiology group;
  • Arianne B. van Gageldonk-Lafeber; National Institute for Public Health and the Environment (RIVM)
  • Susan J.M. Hahne; National Institute for Public Health and the Environment (RIVM)
  • Chantal Reusken; National Institute for Public Health and the Environment (RIVM)
  • Mirjam J. Knol; National Institute for Public Health and the Environment (RIVM)
  • Dirk Eggink; National Institute for Public Health and The Environment (RIVM)
Preprint em Inglês | medRxiv | ID: ppmedrxiv-21266735
ABSTRACT
The extent to which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC) break through infection- or vaccine-induced immunity is not well understood. Here, we analyze 28,578 sequenced SARS-CoV-2 samples from individuals with known immune status obtained through national community testing in the Netherlands from March to August 2021. We find evidence for an increased risk of infection by the Beta (B.1.351), Gamma (P.1), or Delta (B.1.617.2) variants compared to the Alpha (B.1.1.7) variant after vaccination. No clear differences were found between vaccines. However, the effect was larger in the first 14-59 days after complete vaccination compared to 60 days and longer. In contrast to vaccine-induced immunity, no increased risk for reinfection with Beta, Gamma or Delta variants relative to Alpha variant was found in individuals with infection-induced immunity.
Licença
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Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Estudo prognóstico Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Estudo prognóstico Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
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