Your browser doesn't support javascript.
loading
Neutralizing Antibody Activity Against SARS-CoV-2 Variants in Gestational Age-Matched Mother-Infant Dyads
Yusuke Matsui; Lin Li; Mary Prahl; Arianna G. Cassidy; Nida Ozarslan; Yarden Golan; Veronica J. Gonzalez; Christine Y. Lin; Unurzul Jigmeddagva; Megan A. Chidboy; Mauricio Montano; Taha Y. Taha; Mir M. Khalid; Bharath Sreekumar; Jennifer M. Hayashi; Pei-Yi Chen; G. Renuka Kumar; Lakshmi Warrier; Alan H.B. Wu; Dongli Song; Priya Jegatheesan; Daljeet S. Rai; Balaji Govindaswami; Jordan Needens; Monica Rincon; Leslie Myatt; Ifeyinwa V. Asiodu; Valerie J. Flaherman; Yalda Afshar; Vanessa L. Jacoby; Amy P. Murtha; Joshua F. Robinson; Melanie Ott; Warner C. Greene; Stephanie L. Gaw.
Afiliação
  • Yusuke Matsui; Gladstone Institutes
  • Lin Li; University of California San Francisco
  • Mary Prahl; University of California San Francisco
  • Arianna G. Cassidy; University of California San Francisco
  • Nida Ozarslan; University of California San Francisco
  • Yarden Golan; University of California San Francisco
  • Veronica J. Gonzalez; University of California San Francisco
  • Christine Y. Lin; University of California San Francisco
  • Unurzul Jigmeddagva; University of California San Francisco
  • Megan A. Chidboy; University of California San Francisco
  • Mauricio Montano; Gladstone Institutes
  • Taha Y. Taha; Gladstone Institutes
  • Mir M. Khalid; Gladstone Institutes
  • Bharath Sreekumar; Gladstone Institutes
  • Jennifer M. Hayashi; Gladstone Institutes
  • Pei-Yi Chen; Gladstone Institutes
  • G. Renuka Kumar; Gladstone Institutes
  • Lakshmi Warrier; University of California San Francisco
  • Alan H.B. Wu; University of California San Francisco
  • Dongli Song; Santa Clara Valley Medical Center
  • Priya Jegatheesan; Santa Clara Valley Medical Center
  • Daljeet S. Rai; Stanford University
  • Balaji Govindaswami; Marshall University Joan C Edwards School of Medicine
  • Jordan Needens; Marshall University Joan C Edwards School of Medicine
  • Monica Rincon; Oregon Health & Science University
  • Leslie Myatt; Oregon Health & Science University
  • Ifeyinwa V. Asiodu; University of California San Francisco
  • Valerie J. Flaherman; University of California San Francisco
  • Yalda Afshar; University of California Los Angeles
  • Vanessa L. Jacoby; University of California San Francisco
  • Amy P. Murtha; University of California San Francisco
  • Joshua F. Robinson; University of California San Francisco
  • Melanie Ott; Gladstone Institutes
  • Warner C. Greene; Gladstone Institues
  • Stephanie L. Gaw; University of California San Francisco
Preprint em Inglês | medRxiv | ID: ppmedrxiv-21267557
ABSTRACT
Pregnancy confers unique immune responses to infection and vaccination across gestation. To date, there is limited data comparing vaccine versus infection-induced nAb to COVID-19 variants in mothers during pregnancy. We analyzed paired maternal and cord plasma samples from 60 pregnant individuals. Thirty women vaccinated with mRNA vaccines were matched with 30 naturally infected women by gestational age of exposure. Neutralization activity against the five SARS-CoV-2 Spike sequences was measured by a SARS-CoV-2 pseudotyped Spike virion assay. Effective nAbs against SARS-CoV-2 were present in maternal and cord plasma after both infection and vaccination. Compared to wild type or Alpha variant Spike, these nAbs were less effective against the Kappa, Delta, and Mu Spike variants. Vaccination during the third trimester induced higher nAb levels at delivery than infection during the third trimester. In contrast, vaccine-induced nAb levels were lower at the time of delivery compared to infection during the first trimester. The transfer ratio (cord nAb level/maternal nAb level) was greatest in mothers vaccinated in the second trimester. SARS-CoV-2 vaccination or infection in pregnancy elicit effective nAbs with differing neutralization kinetics that is impacted by gestational time of exposure. Vaccine induced neutralizing activity was reduced against the Delta, Mu, and Kappa variants. Graphic abstract O_FIG O_LINKSMALLFIG WIDTH=155 HEIGHT=200 SRC="FIGDIR/small/21267557v1_ufig1.gif" ALT="Figure 1"> View larger version (34K) org.highwire.dtl.DTLVardef@4225dborg.highwire.dtl.DTLVardef@c35b5borg.highwire.dtl.DTLVardef@1a2d180org.highwire.dtl.DTLVardef@6863c2_HPS_FORMAT_FIGEXP M_FIG C_FIG
Licença
cc_by_nc_nd
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
...