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Vaccine breakthrough and the invasion dynamics of SARS-CoV-2 variants
Preprint
em Inglês
| medRxiv
| ID: ppmedrxiv-21267725
ABSTRACT
Vaccination provides a powerful tool for mitigating and controlling the COVID-19 pandemic. However, a number of factors reduce these potential benefits. The first problem arises from heterogeneities in vaccine supply and uptake from global inequities in vaccine distribution, to local variations in uptake derived from vaccine hesitancy. The second complexity is biological though several COVID-19 vaccines offer substantial protection against infection and disease, breakthrough reinfection of vaccinees (and subsequent retransmission from these individuals) can occur, driven especially by new viral variants. Here, using a simple epidemiological model, we show that the combination of infection of remaining susceptible individuals and breakthrough infections of vaccinees can have significant effects in promoting infection of invading variants, even when vaccination rates are high and onward transmission from vaccinees relatively weak. Elaborations of the model show how heterogeneities in immunity and mixing between vaccinated and unvaccinated sub-populations modulate these effects, underlining the importance of quantifying these variables. Overall, our results indicate that high vaccination coverage still leaves no room for complacency if variants are circulating that can elude immunity, even if this happens at very low rates.
cc_by_nc_nd
Texto completo:
Disponível
Coleções:
Preprints
Base de dados:
medRxiv
Idioma:
Inglês
Ano de publicação:
2021
Tipo de documento:
Preprint