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mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant
Wilfredo F Garcia-Beltran; Kerri J. St Denis; Angelique Hoelzemer; Evan C. Lam; Adam D. Nitido; Maegan L. Sheehan; Cristhian Berrios; Onosereme Ofoman; Christina C. Chang; Blake M. Hauser; Jared Feldman; David J. Gregory; Mark C. Poznansky; Aaron G. Schmidt; A. John Iafrate; Vivek Naranbhai; Alejandro B. Balazs.
Afiliação
  • Wilfredo F Garcia-Beltran; The Ragon Institute of MGH, MIT, and Harvard
  • Kerri J. St Denis; The Ragon Institute of MGH, MIT and Harvard
  • Angelique Hoelzemer; First Department of Internal Medicine, Division of Infectious Diseases, University Medical Centre Eppendorf, Hamburg, Germany
  • Evan C. Lam; The Ragon Institute of MGH, MIT and Harvard
  • Adam D. Nitido; The Ragon Institute of MGH, MIT and Harvard
  • Maegan L. Sheehan; The Ragon Institute of MGH, MIT and Harvard
  • Cristhian Berrios; Massachusetts General Hospital
  • Onosereme Ofoman; Massachusetts General Hospital
  • Christina C. Chang; Center for the AIDS Programme of Research in South Africa, Durban
  • Blake M. Hauser; The Ragon Institute of MGH, MIT and Harvard
  • Jared Feldman; The Ragon Institute of MGH, MIT and Harvard
  • David J. Gregory; Massachusetts General Hospital
  • Mark C. Poznansky; Massachusetts General Hospital
  • Aaron G. Schmidt; The Ragon Institute of MGH, MIT and Harvard
  • A. John Iafrate; Massassachusetts General Hospital
  • Vivek Naranbhai; Massachusetts General Hospital/ Dana Farber Cancer Institute
  • Alejandro B. Balazs; The Ragon Institute of MGH, MIT and Harvard
Preprint em Inglês | medRxiv | ID: ppmedrxiv-21267755
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ABSTRACT
Recent surveillance has revealed the emergence of the SARS-CoV-2 Omicron variant (BA.1/B.1.1.529) harboring up to 36 mutations in spike protein, the target of vaccine-induced neutralizing antibodies. Given its potential to escape vaccine-induced humoral immunity, we measured neutralization potency of sera from 88 mRNA-1273, 111 BNT162b, and 40 Ad26.COV2.S vaccine recipients against wild type, Delta, and Omicron SARS-CoV-2 pseudoviruses. We included individuals that were vaccinated recently (<3 months), distantly (6-12 months), or recently boosted, and accounted for prior SARS-CoV-2 infection. Remarkably, neutralization of Omicron was undetectable in most vaccinated individuals. However, individuals boosted with mRNA vaccines exhibited potent neutralization of Omicron only 4-6-fold lower than wild type, suggesting that boosters enhance the cross-reactivity of neutralizing antibody responses. In addition, we find Omicron pseudovirus is more infectious than any other variant tested. Overall, this study highlights the importance of boosters to broaden neutralizing antibody responses against highly divergent SARS-CoV-2 variants.
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Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Rct Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint
Texto completo
Adicionar na Minha BVS
Imprimir
XML
Buscar no Google
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Rct Idioma: Inglês Ano de publicação: 2021 Tipo de documento: Preprint