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SARS-CoV-2 virus dynamics in recently infected people - data from a household transmission study
Alexandra M. Mellis; Jennifer K. Meece; Natasha B. Halasa; James D. Chappell; Huong Q McLean; Carlos G Q Grijalva; Kayla E Hanson; Yuwei Zhu; Ahra Kim; Jessica Deyoe; Lynn C. Ivacic; Carrie Reed; H. Keipp Talbot; Melissa A. Rolfes.
Afiliação
  • Alexandra M. Mellis; Centers for Disease Control and Prevention
  • Jennifer K. Meece; Marshfield Clinic Research Institute
  • Natasha B. Halasa; Vanderbilt University Medical Center
  • James D. Chappell; Vanderbilt University Medical Center
  • Huong Q McLean; Marshfield Clinic Research Institute
  • Carlos G Q Grijalva; Vanderbilt University Medical Center
  • Kayla E Hanson; Marshfield Clinic Research Institute
  • Yuwei Zhu; Vanderbilt University Medical Center
  • Ahra Kim; Vanderbilt University Medical Center
  • Jessica Deyoe; Centers for Disease Control and Prevention
  • Lynn C. Ivacic; Marshfield Clinic Research Institute
  • Carrie Reed; Centers for Disease Control and Prevention
  • H. Keipp Talbot; Vanderbilt University Medical Center
  • Melissa A. Rolfes; Centers for Disease Control and Prevention
Preprint em Inglês | medRxiv | ID: ppmedrxiv-22272516
ABSTRACT
We used daily real-time reverse-transcription polymerase chain reaction (rRT-PCR) results from 67 cases of SARS-CoV-2 infection in a household transmission study to examine the trajectory of cycle threshold (Ct) values, an inverse correlate of viral RNA concentration, from nasal specimens collected between April 2020 and May 2021. Ct values varied over the course of infection, across RT-PCR platforms, and by participant age. Specimens collected from children and adolescents showed higher Ct values and adults aged [≥]50 years showed lower Ct values than adults aged 18-49 years. Ct values were lower on days when participants reported experiencing symptoms.
Licença
cc0
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Estudo prognóstico Idioma: Inglês Ano de publicação: 2022 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Tipo de estudo: Estudo prognóstico Idioma: Inglês Ano de publicação: 2022 Tipo de documento: Preprint
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