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Antidepressant drug prescription and incidence of COVID-19: a retrospective cohort study
Oleg O Glebov; Christoph Mueller; Robert Stewart; Dag Aarsland; Gayan Perera.
Afiliação
  • Oleg O Glebov; Qingdao University Medical School; King's College London
  • Christoph Mueller; Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK; South London and Maudsley NHS Foundation Trust, London, UK.
  • Robert Stewart; Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London; South London and Maudsley NHS Foundation Trust, London, UK.
  • Dag Aarsland; Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK; Centre for Age-related research, Stavanger University Hospital, Stavange
  • Gayan Perera; Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK; South London and Maudsley NHS Foundation Trust, London, UK.
Preprint em Inglês | medRxiv | ID: ppmedrxiv-22283507
ABSTRACT
While antidepressant drugs (ADs) have shown some efficacy in treatment of COVID-19, their preventative potential remains unexplored. To investigate association between AD and COVID-19 incidence in the community, we analysed data from community-living, non-hospitalized adults admitted to inpatient care of the South London&Maudsley (SLaM) NHS Foundation Trust during the 1st wave of COVID-19 pandemic in the UK. Prescription of ADs within the period of 1 to 3 months before admission was associated with an approximately 40% decrease in positive COVID-19 test results when adjusted for socioeconomic parameters and physical health. This association was specifically observed for ADs of the Selective Serotonin Reuptake Inhibitor (SSRI) class. These results suggest that ADs, specifically SSRIs, may help prevent COVID-19 infection in the community. Definitive determination of AD preventative potential warrants prospective studies in the wider general population.
Licença
cc_by_nc_nd
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Idioma: Inglês Ano de publicação: 2022 Tipo de documento: Preprint
Texto completo: Disponível Coleções: Preprints Base de dados: medRxiv Idioma: Inglês Ano de publicação: 2022 Tipo de documento: Preprint
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