Hyperoxic preconditioning in partial liver ischemia
Acta cir. bras.
; 29(supl.1): 19-23, 2014. graf
Article
em En
| VETINDEX
| ID: vti-11160
Biblioteca responsável:
BR1.1
Localização: BR68.1
ABSTRACT
PURPOSE:
To evaluate the effect of the hyperbaric oxygen (HBO) treatment as a pre-conditioning for I/R effects in the liver ischemia.METHODS:
Fifty-seven male Wistar rats (260-300g) were submitted to the following procedures SHAM; I/R, rats submitted to I/R, consisting of partial ischemia of 70% of the liver for 90 minutes followed by 15 minutes of reperfusion; HBO I/R 1 ATA, 30 minutes of HBO treatment at the pressure of 1 absolute atmosphere (ATA) during the ischemia time. HBO I/R 2 ATA, 30 minutes of HBO (2 ATA) during the ischemia time. Pre HBO I/R 30', rats submitted to 30 minutes of HBO (2 ATA) immediately before the I/R time. Pre HBO I/R 90', rats submitted to 90 minutes of HBO (2 ATA) immediately before the I/R time.RESULTS:
There was a significant worsening of all the parameters of mitochondrial energy production (state 3, 4, RCR and Swelling) in the I/R group, when compared to the Sham group (I/RCONCLUSION:
The use of hyperbaric oxygen before and during I/R did not improve the production of hepatocellular energy reduced by I/R, nor did it prevent the installation of mitochondrial edema induced by Iischemia/reperfusion.(AU)Palavras-chave
Texto completo:
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Base de dados:
VETINDEX
Assunto principal:
Reperfusão
/
Hiperóxia
/
Isquemia
/
Fígado
/
Mitocôndrias
Limite:
Animals
Idioma:
En
Revista:
Acta cir. bras.
Ano de publicação:
2014
Tipo de documento:
Article